The proteins necessary for signal transduction in cells responding to ligands of the TGF-β family are largely unknown. We have previously identified Mad (Mothers against dpp), a gene that interacts with the TGF-β family member encoded by decapentaplegic (dpp) in Drosophila. Assay of Mad’s role in the DPP-dependent events of embryonic midgut development demonstrates that Mad is required for any ...

JC virus was previously isolated from the urine and from diseased brain of a patient with progressive multifocal leukoencephalopathy. The DNAs of these isolates, MAD-7 and MAD-8 respectively, were shown in this study to be mixtures of several different full-length genomes. By differences in their restriction endonuclease cleavage patterns, the genomes were categorized into two types. Type I DNA...

OBJECTIVE To quantitatively evaluate the effects of the mandibular advancement device (MAD) on changes in the upper respiratory tract during sleep using sleep videofluoroscopy (SVF) in patients with obstructive sleep apnea (OSA). DESIGN Retrospective analysis. SETTING Academic tertiary referral center. PATIENTS Seventy-six patients (68 men and 8 women) who were treated with the MAD for OS...

Although continuous positive airway pressure (CPAP) is a highly efficacious treatment for obstructive sleep apnea (OSA), there is a need for alternative treatment options, such as sleep surgeries and mandibular advancement devices (MADs), to overcome the limitations of CPAP.This study aimed to analyze the therapeutic outcomes of OSA subjects who were treated with a MAD, and to estimate the clin...

The median absolute deviation about the median (MAD) is an important univariate spread measure having wide appeal due to its highly robust sample version. A powerful tool in treating the asymptotics of a statistic is a linearization, i.e., a Bahadur representation. Here we establish both strong and weak Bahadur representations for the sample MAD. The strong version is the first in the literatur...

This paper describes the multivariate alteration detection (MAD) transformation which is based on the established canonical correlation analysis. It also proposes post-processing of the change detected by the MAD variates by means of maximum autocorrelation factor (MAF) analysis. As opposed to most other multivariate change detection schemes the MAD and the combined MAF/MAD transformations are ...

BACKGROUND Evaluation of the efficacy and safety of a mandibular advancement device (MAD) (KlearwayTM) in the treatment of mild-to-moderate obstructive sleep apnea and chronic roncopathy. MATERIAL AND METHODS A randomized, placebo-controlled, double blinded, and crossover clinical trial was conducted. Placebo device (PD) defined as a splint in the centric occlusion that did not induce a mandi...

We prove the consistency of b > א1 together with the existence of a Π11definable mad family, answering a question posed by Friedman and Zdomskyy in [7, Question 16]. For the proof we construct a mad family in L which is an א1-union of perfect a.d. sets, such that this union remains mad in the iterated Hechler extension. The construction also leads us to isolate a new cardinal invariant, the Bor...

Treatment with a mandibular advancement device (MAD) is recommended for mild obstructive sleep apnea (OSA), primary snoring and as a secondary option for Continuous Positive Airway Pressure, because it has better adherence and acceptance. However, edentulous patients do not have supports to hold the MAD. This study aimed to present a possible to OSA treatment with MAD in over complete upper and...