BACKGROUND Endothelial vasodilator dysfunction and carotid intima-media thickening (IMT) are 2 indicators of subclinical cardiovascular disease. We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults. METHODS AND RESULTS As part of the longitudinal Cardiovascular Risk in Young Finns Study, we measured endothelium-dependent brachial a...

BACKGROUND The association of prediabetic states with endothelial dysfunction measured by flow-mediated dilation (FMD) or endothelial biomarker levels remains controversial. We examined data from 5 ethnic groups to determine the association between glucose categories and FMD or endothelial biomarkers. We determined whether these associations vary by ethnic group or body mass index. METHODS AN...

DeVan et al. [1] undertook a comprehensive cross-sectional study involving the independent variables of IFG (impaired fasting glucose) and exercise training status. In keeping with the effects of many other independent variables, including age [2,3], exercise [4], red wine [5] and cardiovascular disease [6], both FMD% [percentage FMD (flow-mediated dilation)] and Dbase (baseline artery diameter...

BACKGROUND Flow-mediated dilatation (FMD) of the peripheral arteries may be impaired in chronic heart failure (CHF), and this could contribute to the increased peripheral resistance and exercise intolerance that occur with this disease. Physical exercise improves the FMD of large conduit arteries in CHF, but whether a similar impairment also occurs in smaller arteries is unknown. The mechanisms...

The aim of this study was to examine the contribution of arterial shear to changes in flow-mediated dilation (FMD) during sympathetic nervous system (SNS) activation in healthy humans. Ten healthy men reported to our laboratory four times. Bilateral FMD, shear rate (SR), and catecholamines were examined before/after 10-min of -35-mmHg lower body negative pressure (LBNP10). On day 1, localized f...

Flow-mediated dilation (FMD) is a noninvasive technique used to measure conduit artery vascular function. Limited information is available on normative FMD values in healthy children and adolescents. The objective of this study was to assess relationships between age and sex with FMD across childhood and adolescence. Nine hundred and seventy-eight asymptomatic children (12 ± 3 yr, range 6-18 yr...

A heat-intolerance (HI) syndrome in cattle in Tanzania was suspected to be associated with previous, clinical foot-and-mouth disease (FMD). A participatory appraisal (PA) method called "matrix scoring" was used to explore livestock-keeper perceptions of association between HI and cattle diseases. A PA method called 'proportional piling' was used to estimate herd incidence of FMD and other disea...

To the Editor: We read with interest the study of Benjamin et al1 investigating clinical correlates of flow-mediated vasodilation (FMD) in a large community (The Framingham Heart study) of almost 3000 patients. The authors demonstrated in stepwise multivariable linear regression models that FMD was inversely related to age, systolic blood pressure, body mass index, lipid-lowering medication, an...

successful disease management requires a rapid and sensitive diagnosis method that can recognize early infection even before the manifestation of its clinical signs. the only available field diagnostic tests for foot-and-mouth disease (fmd) are lateral flow devices, commonly known as chromatographic strips. low sensitivity and inability to detect fmd virus (fmdv) at the serotype level are limit...