Meiotic chromosome segregation occurs in Drosophila oocytes on an acentrosomal spindle, which raises interesting questions regarding spindle assembly and function. One is how to organize a bipolar spindle without microtubule organizing centers at the poles. Another question is how to orient the chromosomes without kinetochore capture of microtubules that grow from the poles. We have characteriz...

In meiosis, a physical attachment, or cohesion, between the centromeres of the sister chromatids is retained until their separation at anaphase II. This cohesion is essential for ensuring accurate segregation of the sister chromatids in meiosis II and avoiding aneuploidy, a condition that can lead to prenatal lethality or birth defects. The Drosophila MEI-S332 protein localizes to centromeres w...

The summertime mei-yu–baiu rainband over East Asia displays considerable interannual variability. A singular value decomposition (SVD) analysis for interannual variability reveals that precipitation anomalies over the mei-yu–baiu region are accompanied by in situ anomalies of midtropospheric horizontal temperature advection. Anomalous warm (cool) advection causes increased (decreased) mei-yu–ba...

Myoclonic epilepsy in infancy (MEI) is a primary generalized epilepsy. According to the literature, the outcome of MEI is usually benign. Here we report a patient who developed myoclonic astatic epilepsy at age four, having been seizure free without antiepileptic drug treatment for 2 years after his recovery from MEI. At age four, a video-EEG-recording showed frequent head nodding (atonic seizu...

In adult stem cell lineages, progenitor cells commonly undergo mitotic transit amplifying (TA) divisions before terminal differentiation, allowing production of many differentiated progeny per stem cell division. Mechanisms that limit TA divisions and trigger the switch to differentiation may protect against cancer by preventing accumulation of oncogenic mutations in the proliferating populatio...

The oocyte-to-embryo transition transforms a differentiated germ cell into a totipotent zygote capable of somatic development. In C. elegans, several oocyte proteins, including the meiotic katanin subunit MEI-1 and the oocyte maturation protein OMA-1, must be degraded during this transition . Degradation of MEI-1 and OMA-1 requires the dual-specificity YAK-1-related (DYRK) kinase MBK-2 . Here, ...

Zielsetzung: Die Evaluierung eines neuartigen monoenergetischen Nachverarbeitungsalgorithmus (MEI+) bei Patienten mit eingeschränkter intrahepatischer Kontrastierung. Material und Methoden: 25 Patienten wurden retrospektiv in der Studie eingeschlossen. Computertomografien des oberen Abdomen in später Kontrastmittelphase, welche im Dual-Energy-Modus (100/140kV) akquiriert wurden, wurden als Mode...

Seizure-suppressor mutations provide unique insight into the genes and mechanisms involved in regulating nervous system excitability. Drosophila bang-sensitive (BS) mutants present a useful tool for identifying seizure suppressors since they are a well-characterized epilepsy model. Here we describe the isolation and characterization of a new Drosophila seizure-suppressor mutant that results fro...

OBJECTIVES The aims were to characterize the movements in cervical dystonia (CD) by using an estimate of the mechanical power and work involved in the movements and to describe this through a movement energy index (MEI). MATERIALS AND METHODS The subjects (patients n = 6, controls n = 6) were seated in front of a screen with a laser pointer attached to a headband while they performed standard...

a Department of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan b Department of Child Care, Southern Taiwan University of Science and Technology, Tainan, Taiwan c Department of Neurosurgery, Liouying, Chi-Mei Medical Center, Tainan, Taiwan d Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan e Department of Medical Research, Chi-Mei Medical Ce...