Myosin II plays a central role in epithelial morphogenesis; however, its role has mainly been examined in processes involving a single cell type. Here we analyze the structure, spatial requirement and regulation of myosin II during C. elegans embryonic elongation, a process that involves distinct epidermal cells and muscles. We developed novel GFP probes to visualize the dynamics of actomyosin ...

PURPOSE In this study the effects of small systematic MLC misalignments and gravitational errors on the quality of Rapidarc treatment plan delivery are investigated with respect to verification measurements with two detector arrays and the evaluation of clinical significance of the error-induced deviations. METHODS Five prostate and six head and neck plans were modified by means of three erro...

The limited use lifetime is a significant drawback of the solid state disk (SSD). When the P/E cycles exceed the nominal endurance limit, the entire SSD is rendered non-functional as worn out. As the low endurance, the MLC Flash based SSD is not suitable used in lifetime-aware applications and the totalbyte-written of conventional MLC SSD is much less than SLC SSD. In this paper, we proposed an...

Introduction: Because of small size of the beamlets in IMRT, physical penumbra is one of the important dosimetric parameters and small changes in the penumbra will have a great impact on the results. The physical penumbra width is defined as the lateral distance between two specified isodose curves at a specified depth of phantom. In this study, after demonstrating the inconsi...

Background: Midwifery led care (MLC) is a model of care in which perinatal care is provided to women throughout different phases of childbirth by a midwife. Objective: This paper aims to provide a literature review on MLC. Methods: A variety of databases and reports were considered to do the literature review on MLC. The search was limited from 1991 to 2011 by using keywords. A total of 50 arti...

7 In this paper, we propose a cancellable fingerprint template technique based on our previous work on multi-line code (MLC) (Wong et al., 2012). The modification and improvement focuses on the change of MLC values and the generation of binary MLC. In addition, an enhanced similarity measure is also proposed to compensate the loss in accuracy for binary MLC, called the dynamically weighted inte...

The mixed lymphocyte culture (MLC) test has been regarded as an in vitro model of the recognition or sensitization phase of the homograft or graft-versus-host reaction. It has been suggested that the graft-versus-host response in vivo is less in xenogeneic combinations than in allogeneic ones and that there is a similar quantitative relationship in MLC responses. Given the above interpretation ...

Although it is well known that mutations in the cardiac regulatory myosin light chain-2 (mlc-2) gene cause hypertrophic cardiomyopathy, the precise in vivo structural and functional roles of MLC-2 in the heart are only poorly understood. We have isolated a mutation in zebrafish, tell tale heart (tel(m225)), which selectively perturbs contractility of the embryonic heart. By positional cloning, ...

Isometrically suspended uteri from estrogen-primed rats were stimulated with prostaglandin F2 alpha and then exposed to relaxin. Relaxin-dependent decreases in the ratio of phosphorylated to total myosin light chains (MLC) and in MLC kinase activity, measured in the presence of 0.5 mg/ml of uterine myosin and the absence and presence of Ca2+-calmodulin (CaM), were observed. The time-course and ...

Mechanisms of Ca2+ sensitization of both myosin light chain (MLC) phosphorylation and force development by protein kinase C (PKC) were studied in permeabilized tonic smooth muscle obtained from the rabbit femoral artery. For comparison, the Ca2+ sensitizing effect of guanosine 5'-O-(gamma-thiotriphosphate) (GTP gamma S) was examined, which had been previously shown to inhibit MLC phosphatase in...