BACKGROUND The aim of this study was to examine the effects of intense physical training on vascular function in streptozotocin-diabetic rats. We focused on the endothelium-dependent relaxation (EDR) induced by acetylcholine (ACh) and stable ADP adenosine-5'- O - (2-thiodiphosphate) (ADPβS). METHODS Control or diabetic male Wistar rats (n=44) were randomly assigned to sedentary or trained gro...

BACKGROUND Like endothelial and smooth muscle cells, vascular adventitial fibroblasts contain a substantial NAD(P)H oxidase superoxide anion (O2-)-generating system activated by angiotensin II (Ang II). Based on the ability of nitric oxide (NO*) to diffuse rapidly through tissue and the fast reaction rate of NO* and O2-, we postulated that the interaction between NO. and adventitial NAD(P)H oxi...

To bridge the gap between educational research and practice, a methodological approach known as educational design research (EDR) has gained influence. In our view, carrying out EDR necessitates balancing three processes: (1) research, (2) design, and (3) change. Using Activity theory as theoretical foundation, we will clarify the processes and the potential tension between these processes.

[1] One of the primary goals for the Visible Infrared Imaging Radiometer Suite (VIIRS) on board the Suomi National Polar-orbiting Partnership is to provide the science and user communities with the data continuity of the Environmental Data Records (EDR) (or Level-2 products) over global oceanic waters for various research and applications, including assessment of climatic and environmental vari...

We have investigated the dependence of the measured optical density on the incident beam energy, field size and depth for a new type of film, Kodak extended dose range (Kodak EDR). Film measurements have been conducted over a range of field sizes (3 x 3 cm2 to 25 x 25 cm2) and depths (d(max) to 15 cm), for 6 MV and 15 MV photons within a solid water phantom, and the variation in sensitometric r...

Yi = f(xi) + εi = g(Θ >xi) + εi, i = 1, . . . , n, is addressed. In the general setup we are interested in, the covariates xi ∈ R, Θ is a d×m orthogonal matrix (ΘΘ = Im∗) and g : R ∗ → R is an unknown function. To be able to estimate Π consistently, we assume that S = Im(Θ) is the smallest subspace satisfying f(xi) = f(ΠSxi), ∀i = 1, . . . , n, where ΠS stands for the orthogonal projector in R ...

Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and I...

We argue for a new research category, named Education-Driven Research (abbreviated EDR), which fills the gap between traditional field-specific Research that is not concerned with educational objectives and Research in Education that focuses on fundamental teaching and learning principles and possibly on their customization to broad areas (such as mathematics or physics), but not to specific di...

Endogenous superoxide anion (O(-)(2)) interferes with the bioactivity of nitric oxide (NO) in endothelium-dependent arterial relaxation (EDR). Using the lucigenin chemiluminescence assay, we measured O(-)(2) in the thoracic and abdominal aortas and the carotid artery of rabbits to determine whether ambient O(-)(2) varies among the three arteries and differentially diminishes the effect of NO. B...