Stanowisko zostało zlokalizowane na piaszczystym pagórku, obszarze zalesionym. Przeprowadzone w latach 1997–1999 prace archeologiczne miały celu zabezpieczenie niszczonego wybieraniem piasku obszaru stanowiska. Łącznie przebadano powierzchnię 4 arów, obrębie których odsłonięto 16 obiektów, a także warstwę kulturową. Na podstawie analizy materiału zabytkowego wydzielono dwa horyzonty osadnicze z...

Diarrheic shellfish poisoning (DSP) is a recurrent gastrointestinal illness in Morocco, resulting from consumption of contaminated shellfish. In order to develop a rapid and reliable technique for toxins detection, we have compared the results obtained by a commercial immunoassay-"DSP-Check" kit" with those obtained by LC-MS. Both techniques are capable of detecting the toxins in the whole fles...

Objective: Azelnidipine, a long-acting dihydropyridine based calcium channel blocker, on oral administration, the drug undergoes extensive first pass metabolism. Delivery of azelnidipine (AZP) via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. In the present study, is to investigate the development and ev...

OBJECTIVE Most comprehensive treatments for PBC include UDCA, combination of methotrexate (MTX), corticosteroids (COT), colchicine (COC) or bezafibrate (BEF), cyclosporin A (CYP), D-penicillamine (DPM), methotrexate (MTX), or azathioprine (AZP). Since the optimum treatment regimen remains inconclusive, we aimed to compare these therapies in terms of patient mortality or liver transplantation (M...

In the present study, is to development of Azelnidipine (AZP) transdermal patches and to study the effect of Dimethyl sulfoxide (DMSO) on drug permeation through across the rat abdominal skin. The transdermal patches were prepared by solvent casting method using different amounts and combination of hydroxyl propyl methyl cellulose (HPMC E15), Ethyl cellulose (EC) and Eudragit RS100 (ERS). The d...

Dinoflagellates are not only important marine primary producers and grazers, but also the major causative agents of harmful algal blooms. It has been reported that many dinoflagellate species can produce various natural toxins. These toxins can be extremely toxic and many of them are effective at far lower dosages than conventional chemical agents. Consumption of seafood contaminated by algal t...

The glucose-6-P-dependent form of glycogen synthetase has been purified about 5,000-fold from yeast extracts. The enzyme was separated from the glucose-6-P-independent form by DEAE-cellulose chromatography and from other proteins by a two-step agarose chromatography, using complex formation with glycogen to change the elution properties of the synthetase. The purified material shows a single ba...

Rabbit antibody specific to the 2-azofluorenyl group (anti2-AzF antibody) was used to investigate the behavior of cellular components capable of binding 2-acetylaminofluorene (2-AAF) in rat livers during the chemical carcinogenesis. The fixation of the anti-2-AzP antibody in vitro by liver sec tions of rats fed or injected with fluorenyl derivatives was quan titatively measured by the radioiodi...

The signal recognition particle (SRP) from Escherichia coli, composed of Ffh protein and 4.5S RNA, mediates membrane targeting of translating ribosomes displaying a signal or signal-anchor sequence. SRP binds at the peptide exit of the large ribosomal subunit. Structural details of the interaction are not known. Here, the position of Ffh or SRP on the ribosome was probed by using site-specific ...