A synthetic, highly active cellulase enzyme suitable for in planta production may be a valuable tool for biotechnological approaches to develop transgenic biofuel crops with improved digestibility. Here, we demonstrate that the addition of a plant derived carbohydrate binding module (CBM) to a synthetic glycosyl hydrolase improved the activity of the hydrolase in releasing sugar from plant biom...

The nature of the substrate that supports epithelial migration in vivo is of interest, particularly with respect to mechanisms of wound healing. Immunofluorescence and electron microscopy were used to search for common substrate components in prototype rabbit corneal wounds: epithelial scrape wounds, in which the corneal or conjunctival epithelium migrated over the denuded lamina densa of the c...

Curriculum-based measurement in reading (CBM-R) and the Measures of Academic Progress (MAP) are assessment tools widely employed for universal screening in schools. Although a large body of research supports the validity of CBM-R, limited empirical evidence exists supporting the technical adequacy of MAP or the acceptability of either measure for universal screening. Purposes of the current stu...

The interaction between cellulase enzymes and their substrates is of central importance to several technological and scientific challenges. Here we report that the binding of cellulose binding modules (CBM) from Trichoderma reesei cellulases Cel6A and Cel7A show a major difference in how they interact with substrates originating from wood compared to bacterial cellulose. We found that the CBM f...

OBJECTIVE Computerized cognitive-bias modification (CBM) protocols are rapidly evolving in experimental medicine yet might best be combined with Internet-based cognitive behavioral therapy (iCBT). No research to date has evaluated the combined approach in depression. The current randomized controlled trial aimed to evaluate both the independent effects of a CBM protocol targeting imagery and in...

CBM development is a major concern in national energy projects. With high investment, high risks and high yield, CBM makes many investors generate the project plans while at the same time expressing concerns regarding risk. Focusing on the development of risk assessment model in CBM development and applications, this paper proposes the CBM development risk assessment model of multi-information ...

We propose an algorithm, CBM-Gen+, to refine case bases for hierarchical and incomplete domains. In these domains, the case bases are the main source of domain information because of the absence of a complete domain theory. CBM-Gen+ revises the existing cases when a new solution is captured. The main purpose of this revision is to reduce inconsistencies in the cases. We will prove that CBM-Gen+...

Many coal seams contain coalbed methane (CBM) yet most of the world’s production comes from the San Juan Basin in the United States. In fact CBM production from this basin of about 0.9 tcf/yr accounts for about 80% of the CBM production in the US (1.2 tcf/yr) and about 60% of world production. Success in the San Juan Basin is not because of increased gas content in the coals compared to coals i...

Case-Base Maintenance (CBM) has two important goals. On the one hand, it aims to reduce the size of the case-base. On the other hand, it has to improve the accuracy of the CBR system. CBM can be represented as a multi-objective optimization problem to achieve both goals. Multi-Objective Evolutionary Algorithms (MOEAs) have been recognised as appropriate techniques for multi-objective optimisati...

Research conducted within the general paradigm of cognitive bias modification (CBM) reveals that emotional biases in attention, interpretation, and memory are not merely associated with emotional disorders but contribute to them. After briefly describing research on both emotional biases and their modification, the authors examine similarities between CBM paradigms and older experimental paradi...