Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitudinal and additive nature of chronic conditions. In this paper, we explore longitudinal comorbidity metrics and their value in predicting mortality....

The paper develops Child-Computer Interaction (CCI) for 86 children including 42 boys and 44 girls aged 4-6 out of four kindergartens in Taipei City, Taiwan. CCIe is an implication of embodied interaction with Kinect. CCIt is tactile interaction with iPad. CCIm is a multimodal interaction, an innovative integration of iPad and Kinect. The effectiveness of the CCI is evaluated by problemsolving ...

Multi input multi output system (MIMO) has become a viable option to meet the demand of high data rate wireless communication. But MIMO system performance is severely affected by the presence of co-channel interference (CCI). CCI cancellation in MIMO channel therefore is a challenging area of research. This paper provides a Kalman Filter based CCI cancellation approach which is connected to pha...

By applying interference-aware channel segregation based dynamic channel assignment (IACS-DCA) algorithm, each access point (AP) can use a channel with low co-channel interference (CCI) in a distributed manner. Interference environment may vary due to e.g., switching on/off of APs. Its adaptability to varying CCI environment has been left as an interesting study. In this paper, we investigate t...

INTRODUCTION AND OBJECTIVES The Charlson comorbidity index (CCI), an indicator of comorbidity, has been used as an adjusting variable in multivariate models. Because of its prognostic value per se for cardiovascular complications after acute myocardial infarction (AMI), we sought to determine the predictive value of the CCI for all-cause mortality and recurrent AMI 30 days and 1 year after the ...

OBJECTIVE To test whether the newly developed comprehensive complication index (CCI) is more sensitive than traditional endpoints for detecting between-group differences in randomized controlled trials (RCTs). BACKGROUND A major challenge in RCTs is the choice of optimal endpoints to detect treatment effects. Mortality is no longer a sufficient marker in studies, and morbidity is often poorly...

This study was designed to investigate the therapeutic effects of saffron (Crocus Sativus L) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (CCI) in rats. Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Sham + saline, CCI + saline, CCI+ saffron (30 mg/kg), CCI +crocin (15 mg/kg) and CCI + crocin (30 mg/...

The mammalian target of rapamycin (mTOR) inhibitor CCI-779 (temsirolimus) is a recently Food and Drug Administration-approved anticancer drug with efficacy in certain solid tumors and hematologic malignancies. In cell culture studies, CCI-779 at the commonly used nanomolar concentrations generally confers a modest and selective antiproliferative activity. Here, we report that, at clinically rel...

The chronically critically ill (CCI) comprise a rapidly growing population of patients who have survived acute critical illness, only to be left with ongoing organ dysfunctions requiring high levels of specialized care for months or years. In many ways, CCI is an "iatrogenic" process, reflecting the ability of modern life support technologies to keep patients alive for prolonged periods of tim...