Patients taking antidepressants, including Clomipramine (CLP), have an increased risk of osteoporotic fracture. However, the effects of CLP on bone metabolism are unknown. Here, we demonstrate that WT mice treated with CLP for 2 weeks had significantly reduced trabecular bone volume and cortical bone thickness, associated with increased osteoclast (OC) numbers, but had no change in osteoblast n...

OBJECTIVE To describe a new sign of cleft lip and palate (CLP), the maxillary gap, which is visible in the mid-sagittal plane of the fetal face used routinely for measurement of nuchal translucency thickness. METHODS This was a retrospective study of stored images of the mid-sagittal view of the fetal face at 11-13 weeks' gestation in 86 cases of CLP and 86 normal controls. The images were ex...

OBJECTIVES (1) to determine the opinion of parents regarding the psychosocial functioning of their child with cleft lip and/or palate (CLP); (2) to identify predictors of psychosocial functioning; and (3) to determine the level of agreement between children with CLP and their parents. PARTICIPANTS One hundred twenty-nine parents of children with CLP and 96 parents of children without CLP part...

INTRODUCTION Plasminogen activator inhibitor 1 (PAI-1) is a key factor in trauma- and sepsis-induced coagulopathy. We examined how trauma-hemorrhage (TH) modulates PAI-1 responses in subsequent cecal ligation and puncture (CLP)-induced sepsis, and the association of PAI-1 with septic outcomes. METHODS Mice underwent TH and CLP 48 h later in three separate experiments. In experiment 1, mice we...

OBJECTIVE Our aim was to determine if the expression pattern of CLP-1 in developing heart is consistent with its role in controlling RNA transcript elongation by transcriptional elongation factor b (P-TEFb) and if the inhibitory control exerted over P-TEFb by CLP-1 is released under hypertrophic conditions. METHODS We performed immunoblot and immunofluorescence analysis of CLP-1 and the P-TEF...

To evaluate the effect of thermocycling on water contact angle (WCA), surface roughness (SR), and microhardness (MH) different CAD-CAM PMMA denture base materials after treatments (conventional laboratory polishing, polishing kit, or sealant). Disk-shaped specimens (10 × 2 mm) 3 PMMAs, AvaDent (AV); Merz M-PM (M-PM); Polident (Poli), a conventional heat-polymerized (Vynacron) (CV) (n=21) were d...

Leukotrienes (LTs) are proinflammatory lipid mediators derived from polyunsaturated arachidonic acid, which is ester-bound at the sn-2 position of glycerol in cellular phospholipid bilayers. In LTs biosynthesis, 5-lipoxygenase (5-LO) represents the key enzyme, which catalyzes two initial steps. The aim of present thesis was to investigate the effects of a small 5-LO binding protein named Coacto...

We tested in B6 mice whether the local expansion of CD4 T cells producing proinflammatory cytokines including IL-17 (Th17 cells) in the colonic lamina propria (cLP) depends on the commensal microflora. High numbers of CD4 Th17 cells were found in the lamina propria of the ileum and colon but not the duodenum, jejunum, mesenteric lymph nodes, spleen, or liver of specific pathogen-free (SPF) mice...

This study aimed to investigate the effects of nonlinear and linear varied practice compared a constant on inhibitory control reaction time, which are capacities that involve cognition in preadolescents. Eighty-three participants 8th grade participated study. They were assigned two experimental groups (varied practice), taught using pedagogy (NLP) (VLP), respectively, or one group (constant (CL...

Non-syndromic (NS) cleft lip (CL) and with palate (CLP) are abnormalities in the orofacial area that not accompanied by head neck have normal physical growth cognitive development. Cleft CLP caused two factors, genetic environmental factors which include deficiencies of micronutrients such as folate vitamin B12. This study aimed to determine differences B12 serum levels between mothers whose ch...