Tricyclic antidepressant (TCA) overdose is a relatively common cause of poisoning. According to the American Association of Poison Control Centers, 7961 patients with amitriptyline poisoning were reported in 2000. Of these, 958 were under 6 years old, 6388 needed treatment in a health care facility and 68 patients died [1]. The current therapy of TCA overdose includes preventive measures such a...

cis-4-Hydroxy-L-proline (CHP) is being clinically evaluated as an anticancer drug. Since this compound targets the production of L-proline-rich proteins and critical L-proline residues, its impact on long-term cultures of human hepatocytes and toxicity in rats was studied to investigate possible effects on hepatic function, previously reported in rat hepatocytes. In the HEPAC2 human hepatocyte ...

Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are regulated by the second messenger signalling molecule adenosine 3', 5'-cyclic monophosphate (cAMP). Production of cAMP by the putative adenylate cyclase enzyme CyaB represents a critical control point for virulence gene regulation. To identify regulators of CyaB, we screened a transposon insertion library for mu...

We encapsulated tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles. In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine adjuvant. TNF/CHP nanoparticles showed excellent storage stability and enhanced host immune responses to external immunogens. The nanoparticles wer...

Power and heat are the primary energies for the industry and communities. Combined heat and power (CHP) is a process of heat and power cogeneration, which is designed to meet the needs of both users. In previous studies of emergy analysis on CHP, the transformity was simply calculated by dividing the total emergy input by the amount of production. The result always showed that transformity of e...

Background. The increased practice of traditional Chinese medicine (TCM) worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs) among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated fr...

We prepared two types of cholesterol hydrophobically modified pullulan nanoparticles (CHP) and carboxyethyl hydrophobically modified pullulan nanoparticles (CHCP) substituted with various degrees of cholesterol, including 3.11, 6.03, 6.91 and 3.46 per polymer, and named CHP-3.11, CHP-6.03, CHP-6.91 and CHCP-3.46. Dynamic laser light scattering (DLS) showed that the pullulan nanoparticles were 8...

The Combined Heat and Power (CHP) concept is aptly suited to improve or eliminate some of the global and local issues concerning electric commercial buildings. CHP involves on-site or near-site generation of electricity by using gas-fired equipment along with utilization of thermal energy available from the power generation process. CHP has the potential of providing a 30% improvement over conv...

PURPOSE Proliferative vitreoretinopathy (PVR) is characterized by the proliferation and migration of retinal pigment epithelial (RPE) and other cells into the vitreous cavity. The PVR membrane formation also is associated with collagen production by RPE. The authors examined the effect of a proline analog, cis-hydroxyproline (CHP), on proliferation, collagen synthesis, attachment, and migration...

The effect of 4-cis-hydroxy-L-proline (CHP), a proline analogue, on the anchorage-dependent and -independent growth of several transformed rodent cell lines was studied. Mouse NIH-3T3 fibroblasts transformed by a variety of different oncogenes (Ki-ras, mos, src, fms, fes, met, and trk) by a DNA tumor virus (SV40) or by a chemical carcinogen (N-methylnitrosourea) were all found to be more sensit...