نتایج جستجو برای: ن vaca
تعداد نتایج: 5738 فیلتر نتایج به سال:
Helicobacter pylori VacA is a secreted toxin that induces multiple structural and functional alterations in eukaryotic cells. Exposure of VacA to either acidic or alkaline pH ('activation') results in structural changes in the protein and a marked enhancement of its cell-vacuolating activity. However, the mechanism by which activation leads to increased cytotoxicity is not well understood. In t...
OBJECTIVE Prior reports suggested that infection with Helicobacter pylori was associated with respiratory diseases; pathogenetic mechanisms however, were not defined. We tested the hypothesis that VacA, an exotoxin of H. pylori, a gastric pathogen, was aspirated into the lung and could stimulate secretion of inflammatory cytokines by lung epithelial cells. METHODS The presence of VacA was det...
The major secreted virulence factor of Helicobacter pylori, the vacuolating cytotoxin VacA, is known to insert into eukaryotic membranes and has been observed in association with the surface of H. pylori cells that are actively producing it. Here, it is demonstrated that VacA is capable of interacting with the surface of H. pylori and Escherichia coli after secretion. It is shown that this inte...
Background: Helicobacter pylori vacA (vacuolating toxin A) gene is comprised of mid- (m), intermediate- (i) and signal-regions. Recently, the vacA-i region genotype has been suggested to be a better predictor of disease severity than either the s- or m-region. The main aim of the present study was to determine the associations of i region poly-morphisms of vacA gene with gastric cancer (GC) and...
كچ ي هد :فده و هقباس و ينميا رب رچسوپ لرتنك رد للاتخا تيلاعف ماگنه رد تاكرح تيفيك اه ي و هرمزور ريرايا ييشزرو يم رب رروم لماوع زا يكي .دراذگ رچسوپ لرتنك فاطعنا يم تلاضع يريذپ يلع .دشاب اتتيسن عويش مغر يهاياوك داييز ه رد ،گنيرتسمه هلضع ي چ هعلاطم طاتارا يا ن يسررب لداعا اب هلضع نيا يهااوك هديش هيعلاطم نييا زا فديه .تيسا و كيااتسا لداعا اب گنيرتسمه هلضع يهااوك طاتارا يسررب يم ملاس...
The predominant Helicobacter pylori strains circulating among geographic locations differ in regard to genomic structure. The association of the cagA-positive, vacA s1 genotypes with peptic ulcer disease (PUD) and gastric cancer was reported in Western countries but not in East Asian countries. Strains from Western countries predominantly possessed cagA type 2a, vacA s1a or s1b/m1a, or vacA m2a...
Helicobacter pylori bacteria colonize the human stomach where they stimulate a persistent inflammatory response. H. pylori is considered noninvasive; however, lipopolysaccharide (LPS)-enriched outer membrane vesicles (OMV), continuously shed from the surface of this bacterium, are observed within gastric epithelial cells. The mechanism of vesicle uptake is poorly understood, and this study was ...
We compared four tests for antibodies to CagA or VacA, HelicoBlot 2. 0, RIDA Blot Helicobacter, CHIRON RIBA H. pylori SIA, and an enzyme-linked immunosorbent assay using recombinant CagA. Immunoblot assays were accurate for determining Helicobacter pylori status but poor for determining CagA or VacA status (accuracy, 66 to 80% for CagA status and 34 to 67% for VacA status). None can be recommen...
O artigo de Lins et al.1 é um estudo importante porque ressalta vários fatores-chave da alergia à proteína do leite de vaca. Os pesquisadores identificaram, com base na história, 66 pacientes com reações adversas à proteína do leite de vaca. Essas reações incluíam uma variedade de sintomas cutâneos, gastrointestinais e sistêmicos. Mediram-se os níveis de imunoglobulina E (IgE) sérica total e es...
Helicobacter pylori, the causative agent of gastritis and ulcer disease in humans, secretes a toxin called VacA (vacuolating cytotoxin) into culture supernatants. VacA was initially characterized and purified on the basis of its ability to induce the formation of intracellular vacuoles in tissue culture cells. H. pylori strains possessing different alleles of vacA differ in their ability to exp...
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