The heterocyclic amines (HCAs) found in cooked meat are procarcinogens that are metabolically activated by N-hydroxylation followed by O-acetylation by the N-acetyltransferases NAT1 and NAT2. Despite the importance of metabolic activation in HCA carcinogenicity and the finding that several HCAs are rodent mammary gland carcinogens, nothing was known about O-acetylation activity in the human mam...

The reaction of zinc chloride and 2-methyl-8-hydroxy-quinoline in methanol yielded the title monosolvated salt, (C(10)H(10)NO)[ZnCl(2)(C(10)H(8)NO)]·CH(3)OH, which has the Zn atom within a distorted Cl(2)NO tetra-hedral coordination geometry. Supra-molecular chains feature in the crystal structure, comprising all components of the structure stabilized by a combination of O-H⋯O, N-H⋯O and O-H⋯Cl...

Gold nanoparticles (AuNPs) modified by 8-hydroxy-quinoline (8-HQ) and stabilized by polyvinylpyrrolidone (PVP) were used for highly selective and sensitive colorimetric detection of Hg(2+) based on the quick aggregation of AuNPs leading to a color change from wine red to gray. The limit of Hg(2+) detection in real environmental water samples is 4.0 × 10(-7) M by the naked eyes and 1.0 × 10(-8) ...

A series of 1-(4-methylquinolin-2-yl)-4,6-diaryl-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives was synthesized by the reaction of 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones with 2-chloro-4,6-diphenylnicotinonitrile analogues in the presence of 2-hydrazino-4-methyl quinoline and ethanol. The newly synthesized compounds were characterized by IR, 1H NMR and mass spectral data. The synthetic se...

Quinoline and naphthalene-based fluororeceptors 1 and 2 have been designed and synthesized for detection of hydroxy carboxylic acids in less polar solvents. The receptor 1 shows monomer emission quenching followed by excimer emission upon hydrogen bond-mediated complexation of carboxylic acids. The excimer emission distinguishes aromatic dicarboxylic acids from aliphatic dicarboxylic acids and ...

8-Hydroxyquinoline-based receptors 1-3, containing a trisubstituted triethylbenzene core, were prepared and their binding properties towards glycosides were evaluated. (1)H NMR and fluorescence titrations as well as binding studies in two-phase systems, such as dissolution of solid carbohydrates in apolar media and phase transfer of sugars from aqueous into organic solvents, revealed β- vs.α-an...

New europium complexes of 3-oxo-1-hydroxy-quinoline-2-carboxylic acid amide derivatives (L1-L3), which are highly luminescent and do not require luminescence enhancers are reported. The luminescence intensity of the Eu-L1-3 complexes was enhanced by the addition of citrate ions in water solution. A sensitive luminescence enhancement system was developed for the determination of citrate ions on ...

Two new Cr(III) complexes based on 2-substituted 8-hydroxyquinoline ligands, namely [Cr(L₁)₃] (1), (HL₁=(E)-2-[2-(4-nitro-phenyl)-vinyl]-8-hydroxy-quinoline) and [Cr(L₂)₃] (2), (HL₂=(E)-2-[2-(4-chloro-phenyl)vinyl]-8-hydroxy-quinoline), were prepared by a facile hydrothermal method and characterized thoroughly by single crystal X-ray diffraction, powder X-ray diffraction, FTIR, TGA, ESI-MS, UV-...