نتایج جستجو برای: پلیمر plga

تعداد نتایج: 7972  

Journal: :International journal of clinical and experimental medicine 2015
Xiaolong Tang Ronghong Jiao Chunmei Xie Lifa Xu Zhen Huo Jingjing Dai Yunyun Qian Weiwen Xu Wei Hou Jiang Wang Yong Liang

To develop amphotericin B-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles (PLGA-TPGS-AMB NPs) for fungal infection treatment, PLGA-TPGS NPs and PLGA NPs were synthesized by a modified double emulsion method and characterized in terms of size and size distribution, morphology and zeta potential. Drug encapsulation efficiency, in vitro drug release, and in vitro/vivo tests against Candida...

2017
Shifeng Yan Taotao Wang Xing Li Yuhang Jian Kunxi Zhang Guifei Li Jingbo Yin

Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(L-glutamic acid)/chitosan (PLGA/CS) hydrogels were fabricated by selfcrosslinking aldehyde-modified PLGA (PLGA–CHO) and lactic acid-modified chitosan (CS–LA). The oxidation degree of PLGA–CHO and degree of substitution (DS) of CS–LA could be adjusted by the amount o...

Journal: :Materials science & engineering. C, Materials for biological applications 2013
Manjari Bhamidipati BanuPriya Sridharan Aaron M Scurto Michael S Detamore

The aim of this study was to use CO2 at sub-critical pressures as a tool to sinter 3D, macroporous, microsphere-based scaffolds for bone and cartilage tissue engineering. Porous scaffolds composed of ~200 μm microspheres of either poly(lactic-co-glycolic acid) (PLGA) or polycaprolactone (PCL) were prepared using dense phase CO2 sintering, which were seeded with rat bone marrow mesenchymal strom...

2010
Yuandong Ma Yi Zheng Kexin Liu Ge Tian Yan Tian Lei Xu Fei Yan Laiqiang Huang Lin Mei

Cancer is the leading cause of death worldwide. Nanomaterials and nanotechnologies could provide potential solutions. In this research, a novel biodegradable poly(lactide-co-glycolide)-d-a-tocopheryl polyethylene glycol 1000 succinate (PLGA-TPGS) random copolymer was synthesized from lactide, glycolide and d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) by ring-opening polymerization u...

Journal: :Journal of colloid and interface science 2008
Yunqing Kang Guangfu Yin Ping Ouyang Zhongbing Huang Yadong Yao Xiaoming Liao Aizheng Chen Ximing Pu

In this work, poly(L-lactic acid)/poly(lactide-co-glycolide) (PLLA/PLGA) microparticles were prepared using the technique of solution-enhanced dispersion by supercritical fluids (SEDS). For comparison, separate PLLA and PLGA microparticles were also produced by the same SEDS process. The produced microparticles were characterized by scanning electron microscopy, laser particle size analyzer, X-...

2013
Yongxia Chen Ziying Yang Chao Liu Cuiwei Wang Shunxin Zhao Jing Yang Hongfan Sun Zhengpu Zhang Deling Kong Cunxian Song

BACKGROUND Star-shaped polymers provide more terminal groups, and are promising for application in drug-delivery systems. METHODS A new series of six-arm star-shaped poly(lactic-co-glycolic acid) (6-s-PLGA) was synthesized by ring-opening polymerization. The structure and properties of the 6-s-PLGA were characterized by carbon-13 nuclear magnetic resonance spectroscopy, infrared spectroscopy,...

Journal: :International journal of pharmaceutics 2015
Yung-Chih Kuo Yu-Chun Chen

Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs (Lf/FA/PLGA NPs) were employed to permeate the monolayer of human brain-microvascular endothelial cells (HBMECs) regulated by human astrocytes an...

2014
Fatemeh Ajalloueian Hossein Tavanai Jöns Hilborn Olivier Donzel-Gargand Klaus Leifer Abeni Wickham Ayyoob Arpanaei

Novel nanofibers from blends of polylactic-co-glycolic acid (PLGA) and chitosan have been produced through an emulsion electrospinning process. The spinning solution employed polyvinyl alcohol (PVA) as the emulsifier. PVA was extracted from the electrospun nanofibers, resulting in a final scaffold consisting of a blend of PLGA and chitosan. The fraction of chitosan in the final electrospun mat ...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2011
Christopher Schliehe Constanze Schliehe Marc Thiry Ulrich I Tromsdorf Joachim Hentschel Horst Weller Marcus Groettrup

Biodegradable poly-(D,L-lactide-co-glycolide) microspheres (PLGA-MS) are approved as a drug delivery system in humans and represent a promising antigen delivery device for immunotherapy against cancer. Immune responses following PLGA-MS vaccination require cross-presentation of encapsulated antigen by professional antigen presenting cells (APCs). While the potential of PLGA-MS as vaccine formul...

2011
Weijie Chen Sanyuan Hu

BACKGROUND Particulate carriers are necessary to control the release of endostar and prolong its circulation in vivo. The purpose of this study was to identify a suitable carrier for the capsulation and delivery of endostar. METHODS We prepared a series of poly (DL-lactide-co-glycolide) (PLGA) and poly (ethylene glycol) (PEG)-modified PLGA (PEG-PLGA) particulate carriers, and then characteriz...

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