We studied the effects of 5-ethynyluracil (776C85 and 776C), a potent mechanism-based inactivator of dihydropyrimidine dehydrogenase, on the antitumor efficacy and pharmacokinetics of tegafur (FT), a prodrug of 5-fluorouracil (5-FU), in rats with large s.c. colon carcinoma. Rats were dosed p.o. once daily for 7 days with either FT, FT and uracil in a 1:4 molar ratio (UFT), FT 1 h after 776C (77...

this research is aimed to undertake a comparative study on stability and thermal degradation kinetics of un-irradiated and high energy protons irradiated polyvinyl butyral (pvb) based on weight loss analysis and non-isothermal approaches. the weight loss by the un-irradiated pvb upon heating was found to be in two stages but due to high energy protons accelerated exposure following by chemical ...

background: n-acyl homoserine lactone (ahl) is found to be the main component of quorum sensing (qs) in gram-negative bacteria and plays an important role in biofilm formation. little information is available regarding the role of ahl in biofilm formation in escherichia coli (e. coli). the purpose of this investigation was to biochemically detect and characterize ahl activity in biofilm-forming...

OBJECTIVE The aim of this study in pregnant women with hypothyroidism treated by levothyroxine is to examine the interrelations between thyroid-stimulating hormone (TSH), free thyroxine (FT(4)) and free tri-iodothyronine (FT(3)), and examine whether in such patients the treatment is adequate. METHODS This was a retrospective cross-sectional study. Maternal serum concentrations of FT(3), FT(4)...

PURPOSE To compare reduced colonic cleansing based on dietary fecal tagging (FT) with standard (non-FT) colonic cleansing with regard to patient acceptance, sensitivity, and specificity. MATERIALS AND METHODS In 50 patients (FT group), FT was performed by means of diet, magnesium citrate, and a barium suspension. In another 50 patients (non-FT group), preparation was based on polyethylene gly...

BACKGROUND The growing interest in measuring blood free testosterone (FT) is constrained by the unsuitability of the laborious reference methods for wider adoption in routine diagnostic laboratories. Various alternative derived testosterone measures have been proposed to estimate FT from either additional assay steps or calculations using total testosterone (TT) and sex hormone-binding globulin...