protein quantitation that obtains precise and sensitive measurements of specific target analytes in complex biological samples. Prior to performing MRM, many peptide analytes require an enrichment step to achieve sufficient sensitivity in the assay. Coupling a peptide immunoaffinity enrichment step to MRM (i.e. an immuno-MRM assay) is effective for most analytes and provides high sensitivity an...

We demonstrate the use of high-resolution three-dimensional magnetic resonance microscopy (3D MRM) for anatomical studies of woody tissues. Samples of normal and pathological structures in the branches of four tree species were imaged by 3D MRM immediately after removal from the tree, without additional tissue preparation. MRM data sets were displayed in 2D sections and in a 3D volume rendered ...

Multiple Reaction Monitoring (MRM) conducted on a triple quadrupole mass spectrometer allows researchers to quantify the expression levels of a set of target proteins. Each protein is often characterized by several unique peptides that can be detected by monitoring predetermined fragment ions, called transitions, for each peptide. Concatenating large numbers of MRM transitions into a single ass...

The multiplicative renormalization method (MRM) is intorduced to obtain generating functions of orthogonal polynomials of given probability measures. Complete lists of MRM-applicable measures for MRM-factors h(x) = ex and (1 − x)−· were obtained recently. On the other hand, it is known that gamma distributions have at least two types of MRM-factors h(x) = 0F1(−;·;x) and h(x) = 1F1(c;·;x). The u...

Based on theoretically calculated comprehensive lipid libraries, in lipidomics as many as 1000 multiple reaction monitoring (MRM) transitions can be monitored for each single run. On the other hand, lipid analysis from each MRM chromatogram requires tremendous manual efforts to identify and quantify lipid species. Isotopic peaks differing by up to a few atomic masses further complicate analysis...

Magnetic Resonance Microscopy (MRM) can provide high microstructural detail in excised human lesions. Previous MRM images on some experimental models and a few human samples suggest the large potential of the technique. The aim of this study was the characterization of specific morphological features of human brain tumor samples by MRM and correlative histopathology. We performed MRM imaging an...

Background Phase contrast MRI has limited practical value in clinical applications due to its inherently long scan times [Kilner,JCMR’07]. Parallel imaging[Pruessmann, MRM’01] and spatio-temporal constrained reconstruction techniques[Tsao,MRM’03] have been shown beneficial[Baltes,MRM’05]. Dual slice approaches have shown advantages as compared to standard SENSE when multiple and sufficiently se...