Xanthine oxidoreductase (XOR) is a cytoplasmic molybdenum-containing oxidoreductase, catalyzing both endogenous purines and exogenous compounds. It is suggested that XOR in porcine hepatocytes catalyzes the N-oxide reduction of quinoxaline 1,4-di-N-oxides (QdNOs). To elucidate the molecular mechanism underlying this metabolism, the cDNA of porcine XOR was cloned and heterologously expressed in ...

Acute lung injury (ALI) is characterized by increased alveolar cytokines, inflammatory cell infiltration, oxidative stress, and alveolar cell apoptosis. Previous work suggested that xanthine oxidoreductase (XOR) may contribute to oxidative stress in ALI as a product of the vascular endothelial cell. We present evidence that cytokine induced lung inflammation and injury involves activation of XO...

With the advancement of technology, power consumption and higher speed becomes major concern for VLSI systems. In this paper, a new hybrid domino XOR is proposed and compared with existing domino XOR cell. As an application of proposed XOR cell, 1-bit full adder has been designed and compared with a full adder circuit using existing XOR cell. Both proposed designs XOR and full adder show better...

BACKGROUND Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. XOR also produces free radicals serving as second messenger and microbicidal agent. Large variation in the XO activity has been observed among various species. Both...

| The use of XOR gates has shown several advantages in modern circuit design, e.g. smaller representation size and better testability. In this paper we consider power consumption in XOR dominated circuits and compare such designs with traditional AND/OR logic. We investigate the suitability of using diierent delay models such as unit delay, fanout delay, and random delay in power estimation of ...

| The use of XOR gates has shown several advantages in modern circuit design, e.g. smaller representation size and better testability. In this paper we consider power consumption in XOR dominated circuits and compare such designs with traditional AND/OR logic. We investigate the suitability of using di erent delay models such as unit delay, fanout delay, and random delay in power estimation of ...

Xanthine oxidoreductase (XOR) plays a prominent role in acute lung injury because of its ability to generate reactive oxygen species. We investigated the role of XOR in ventilator-induced lung injury (VILI). Male C57BL/6J mice were assigned to spontaneous ventilation (sham) or mechanical ventilation (MV) with low (7 ml/kg) and high tidal volume (20 ml/kg) for 2 h after which lung XOR activity a...