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Frorn the Neonatal Division, Department of Pediatrics, ]awaharlal Institute of PostGraduate Medical Education and Research Pondicherry 605 006. Reprint requests: Dr. B. Vishnu Bhat, Professor of Pediatrics, Jawaharlal Institute of Post-Graduate Medical Education and Research, Pondicherry 605 006. Received for publication: August 1,1995; Accepted: October 9,1995 anomalies is endless. The reporte...
Introduction Tumor Necrosis Factor Receptor (TNFR) Associated Periodic Syndrome (TRAPS) is a dominant autoinflammatory disorder caused by heterozygous mutations in TNFRSF1A, the gene encoding the TNFalpha receptor 1 (TNFR1). TNFRSF1A mutations induce aberrant localization and accumulation in aggregates of the mutant TNFR1 proteins, elevated levels of reactive oxygen species (ROS) and excessive ...
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