OBJECTIVE UCN-01 (7-hydroxystaurosporine) is a small molecule cyclin-dependent kinase modulator currently under clinical development as an anticancer agent. In vitro studies have demonstrated that UCN-01 is strongly bound to the acute-phase reactant alpha (1)-acid glycoprotein (AAG). Here, we examined the role of protein binding as a determinant of the pharmacokinetic behavior of UCN-01 in pati...

Assignor This report contains the results from research carried out under two separate contracts: BOLK: Beleidsgericht Onderzoeksprogramma Lucht en Klimaat 2008-2009, sponsored by the Dutch Ministry of VROM and coordinated by the Netherlands Environmental Assessment Agency MNP (contract nr. M/500146/01/TNO and M/500146/01/CE); Literatuurstudie naar de emissies van biobrandstoffen en andere alte...

Injection of steroid-free bovine follicular fluid (bFF; 2 \m=x\5 ml s.c. 12h apart) into anoestrous ewes lowered plasma FSH concentrations by 70% and after 24 h had significantly (P < 0\m=.\01)reduced the number of non-atretic follicles (\m=ge\1 mm diam.) without influencing the total number of follicles (\m=ge\1 mm diam.) compared to untreated controls. Hourly injections of FSH (10 \g=m\gi.v. ...

INTRODUCTION Pulmonary insufficiency (PI) frequently develops in patients who underwent repair of tetralogy of fallot (TOF). The aim of present study was to assess the effect of pulmonary valve replacement (PVR) on hemodynamics of patients who underwent repair of TOF. METHODS This retrospective cohort carried out between July 2010 and October 2012 among consecutive PVRs of 19 patients who und...

A multigraph is (k, r)-dense if every k-set spans at most r edges. What is the maximum number of edges exN(n, k, r) in a (k, r)-dense multigraph on n vertices? We determine the maximum possible weight of such graphs for almost all k and r (e.g., for all r > k) by determining a constant m = m(k, r) and showing that exN(n, k, r) = m ( n 2 ) +O(n), thus giving a generalization of Turán’s theorem. ...

A combination of solid phase extraction (SPE) columns was used for selective separation of water-soluble arsenic species: arsenite, arsenate, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). The SPE columns, namely AnaLig TE-01 (TE-01), AnaLig AN-01 Si (AN-01) and AnaLig As-01 PA (As-01), contain immobilized macrocyclic material as the sorbent and commonly known as molecular recogni...

introduction: in order to study the effects of turpentine oil on the concentration of lipids and lipoproteins of rabbit ( as an animal model for human studies )35 healthy female rabbits were chosen and then randomly allocated into 13 groups. different percents of turpentine oil and other oil compounds like vegetable oil, cholesterol and animal oil were given to each group ( 5 rabbits ) separate...

From e.m.f measurements of cells (C-1) and (C-2) it has been established that modified Davies equation is valid in dioxane-water media at least upto 30% dioxane by weight. E0m values Hg | Hg2Cl2(s), Cl- electrode having 10, 20 weight the corresponding thermodynamic parameters have determined 288.15, 298.15, 308.15 318.15 0K. (Pt),H2 ( l atm ) HCl(m1) x% Dioxane (100-x)% H2O, Hg2Cl2(s) … BaCl2(m...

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