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Introduction Hyperzincaemia and hypercalprotectinaemia (Hz/Hc), a rare condition within the spectrum of autoinflammatory diseases, is associated with hepatosplenomegaly, arthritis, anemia, cutaneous inflammation, and failure to thrive. So far, no genetic cause has been identified. While the clinical appearance is heterogeneous, all affected individuals present with extremely elevated MRP8/MRP14...
In this assignment, the goal was to parse a large set of Wikipedia articles, to extract features into a sparse feature matrix and to cluster them with a clustering algorithm of our choice. One motivation to perform automated clustering on unstructured, unlabeled data is to detect correlations between data points; for instance, in the case of Wikipedia, one might be able to automatically group a...
Introduction Familial Mediterranean fever (FMF) is an autosomal recessive disease, mainly affecting Jews, Armenians, Turks, Arabs and other groups living around Mediterranean basin. Major symptoms of disease are recurrent periodic fever accompanied by serositis. The disease is usually diagnosed at ages less than 20 years. Onset of the disease at older age can rarely occur. Symptoms related to F...
BACKGROUND Newborns display distinct immune responses that contribute to susceptibility to infection and reduced vaccine responses. Toll-like receptor (TLR) agonists may serve as vaccine adjuvants, when given individually or in combination, but responses of neonatal leukocytes to many TLR agonists are diminished. TLR8 agonists are more effective than other TLR agonists in activating human neona...
Inventory represents a significant investment of capital for most companies. Inventory ties up money that could be used more productively elsewhere. Thus, effective inventory management offers the potential for significant cost savings. Furthermore, quality, product engineering, prices, overtime, excess capacity, ability to respond to customers (due-date performance), lead times, and overall pr...
C l i n M e d International Library Citation: Trung D, Bramley D, Nazareth J, Andrews DT (2014) Time and Motion Study Assessment of Simulated Rapid Sequence Intubation. Int J Anesthetic Anesthesiol 1:018. doi. org/10.23937/2377-4630/1/3/1018 Received: December 02, 2014: Accepted: December 23, 2014: Published: December 29, 2014 Copyright: © 2014 Trung D. This is an open-access article distribute...
at the SPTL conference, Glasgow University 2002. I would like to thank Sara Fovargue for her comments on that draft and the anonymous reviewers of Medical Law Review. 1 See further C. Dyer, ‘Surrogate Mother Refuses to Give Up Baby’ (1997) 314 B.M.J. 250 and D. Kennedy, ‘Minister Hints at Change in the Law’ (1997) The Times, 16 May. 2 M. Brazier, A. Campbell and S. Golombok, Surrogacy: Review f...
In this report, we describe our implementation of a linear regression method to classify a numerically-scored sentiment data. The dataset was collected by Mark Dredze and others at Johns Hopkins, which records 1M amazon.com book review. The linear regression classification starts with reading tokenized data and building word counts map, and then training linear classifier by minimizing error te...
BACKGROUND This work evaluated the hypothesis that 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294), an agonist of adenosine A2A receptor, could be beneficial for preventing cardiac dysfunction due to hypertension associated with myocardial infarction (MI). METHODS Male spontaneously hypertensive rats (SHR) were randomly divided into four groups (six animals per group): sham-operati...
Abuse of synthetic cannabinoids (SCs), such as [1-naphthalenyl-(1-pentyl-1H-indol-3-yl]-methanone (JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (AM2201), is increasing at an alarming rate. Although very little is known about the metabolism and toxicology of these popular designer drugs, mass spectrometric analysis of human urine specimens after JWH-018 and AM2201 exp...
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