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Clostridium difficile is the commonest cause of antibiotic-associated diarrhoea, with the hospitalized elderly being at particular risk. The organism makes a crystalline surface protein layer (S-layer), encoded by the slpA gene, the product of which is cleaved to give two mature peptides which associate to form the layer. The larger peptide (high molecular weight; HMW), derived from the C-termi...
A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one] was synthesized with the intention of improving upon the selective cytotoxicity of UA-62784 against human pancreatic cancer cell lines with a deletion of the tumor suppressor gene deleted in pancreas cancer locus 4 (DPC-4, SMAD-4). Over 80 analogs were synthesized...
——————————————— For Correspondence: Vanaja Paul, F–1, Varalakshmi Castle, 3, Akbarabad II Street, Kodambakkam, Chennai – 600 024, India. Lecturer in Zoology, Bharathiar University, Coimbatore – 641 046, India. E-mail: [email protected] Professor of Pharmacology (Retd), University of Madras, Chennai, India. EFFECT OF VITAMIN D ON CHRONIC BEHAVIORAL AND DENTAL TOXICITIES OF SODIUM FLUORIDE ...
BACKGROUND AND PURPOSE Saccular intracranial aneurysm is a common disease that may cause devastating intracranial hemorrhage. Hemodynamics, wall remodeling, and wall inflammation have been associated with saccular intracranial aneurysm rupture. We investigated how saccular intracranial aneurysm hemodynamics is associated with wall remodeling and inflammation of the saccular intracranial aneurys...
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