abstract tuberculosis and diabetes mellitus are the most important reasons in mortality all over the world. it’s clear that reviewing of relationship between tuberculosis (tb) and diabetes mellitus (dm) is necessary; on the other hand it’s found that fto gene has the positive relationship with metabolic issues. therefore, it’s necessary pay attention to the above and dangerous sicknesses, espec...

the gene coding claudin (cldn5) is located on 22q11. since the proteins of cldn5 family are a ma-jor component for barrier-forming tight junctions, it may be important to test whether or not the cldn5 locus could be associated with schizophrenia.a total of 150 individuals affected with schizophrenia and 150 healthy persons were recruited. the relation-ship between the three single nucleotide po...

aim : the purpose of this study was to assess the incidence of 16bp insertion of intron 3 p53 in gastritis lesion and its correlation with clinicopathological aspects. background : p53 alterations have been implicated in the development of gastric malignancies. patients and methods : 97 gastritis and normal adjacent tissues were investigated for p53 gene analysis using pcr-sequencing of intron3...

in this study we estimated the allele and genotype frequencies of scd1 and dgat1 gene polymorphism. the analysis was conducted on 408 holstein cows from five dairy herds in isfahan province. genotypes were identified using pcr-rflp technique. two genetic variants (a and v) of the scd1 gene were observed in this experiment. the frequency of a-allele ranged from 0.49 to 0.66, while frequency of v...

background: pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (rm). objective: to investigate the association between rm and five polymorphisms of cytokine genes, interleukin 10 (il-10), (-592 a/c, -819 c/t, -1082 a/g), il-6 (-174 c/g) and il-17 (-197 g/a) in iranian women. method: po...

tuberculosis is one of the most common infectious diseases in the world. in recent years, genetically approach has been developed. one of the interesting gene for investigator is ifn-γr1. in this study we determind susceptibility to tuberculosis with polymorphism of ifn-γr1 gene. fifthly patients with smear positive tuberculosis have been chosen randomly. they were matched with 54 healthy contr...

in this study the genetic polymorphism of growth hormone (gh) gene as a candidate gene in livestock was investigated. blood samples were randomly collected from 34 alpine and 42 saanen goats. dna was extracted from blood samples and a 365 bp region of exon 5 of the gh genewas amplified by polymerase chain reaction (pcr). pcr products were analyzed using single strand conformation polymorphism (...

fibroblast growth factor 2 (fgf2) serves in the uterine endometrium during estrous presenting in the bovine mammary gland which is responsible to express interferon-t (ifnt), and is an important agent to encourage the continuation of pregnancy in the ruminants. significant associations have been found between genes affected by ifnt and genes that are responsible for milk production traits. seme...

Background & Aims: Vesicoureteral Reflux (VUR) is a congenital defect of the urinary tract which has been reported in approximately 1% of children. Several immunological and genetic factors are listed as major causes of this problem. The C825T polymorphism of the GNB3 gene is among the genetic factors that may be involved in the development or progression of the disease. Participatory role o...

introduction: a thyroid nodule is a palpable swelling in a thyroid gland with an otherwise normal appearance. palpable thyroid nodules occur in 4 to 7 percent of the population. nodular thyroid diseases are more frequent in women than in men. most actions of thyroid hormone are mediated by the active form of thyroid hormone. d2 is essential for formation of active hormone of t3 through deiodina...