294/5545/1317. [3] C. Joachim and M. A. Ratner, Nanotechnology 15, 1065 (2004), URL http://stacks.iop.org/0957-4484/

A theoretical modelling is presented of the covalent adducts of the antitumor agent CC-1065 with B-DNA. The optimal complexes are obtained by energy minimisation, taking into account full structure flexibility, including the flexible rings of the ligand and DNA. The binding preference of CC-1065 with respect to base sequence is studied. The results obtained elucidate the origin of the preferenc...

Vasoconstrictive and Angiogenic Properties , a Novel Hypoxia-Induced Mitogenic Factor in Lung With α FIZZ1/RELM Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000073999.07698.33 2003;92:1065-1067;...

CC-1065 is a very potent antitumor antibiotic which selectively binds in the minor groove of DNA with alkylation at N-3 of adenine. Since therapeutic doses of CC-1065 caused delayed deaths in mice, analogues were synthesized, some of which had significant antitumor activity. The effects of several of these analogues on inhibition of CHO cell survival, cell progression, and their phase-specific ...

This study assesses the prospectivity of world’s oldest known stacked petroleum systems from Proterozoic greater McArthur Basin (Northern Territory, Australia), which has immense potential to host both conventional natural gas and oil, in addition shale-gas accumulations. The Mesoproterozoic succession Beetaloo Sub-basin surrounding region hosts Territory’s premier play is at an advanced stage ...

Previous geochemical and biomarker studies of the late Paleo-Mesoproterozoic propose a stratified world, with strongly reducing (possibly sulfidic) deep-ocean conditions overlain by an oxygenated surface-ocean and atmosphere. To investigate such a scenario, we look to the structure of the biogeochemical sulfur cycle. We present sulfur (S, S, S, and S in sulfides) isotope data from the McArthur ...