OBJECTIVE To determine the clinical usefulness of basal-supported oral therapy (BOT) using insulin glargine in Japanese patients with type 2 diabetes. METHODS We compared HbA1c levels, body weight, and insulin doses before the introduction of BOT and in the final month of the observation period in 122 patients with type 2 diabetes who received BOT with insulin glargine between October 2007 an...

Effect of stimulation of glucokinase (GK) export from the nucleus by small amounts of sorbitol on hepatic glucose flux in response to elevated plasma glucose was examined in 6-h fasted Zucker diabetic fatty rats at 10 weeks of age. Under basal conditions, plasma glucose, insulin and glucagon were ~8 mM, 2000 pmol/l, and 60 ng/l, respectively. Endogenous glucose production (EGP) was 44 ± 4 μmol⋅...

Objective — to optimize of early diagnosis fibrosis in patients with NAFLD obesity and overweight based on ROC analysis non‑invasive laboratory instrumental diagnostic markers. Materials methods. The study included 120 (main group) 1 3 degrees or (BMI ≥25.0 39.9 kg/m2) 20 practically healthy volunteers (control 23.50 [21.35; 24.78] kg/m2. Patients the main group were divided into two subgroups ...

Let G be a finite group and k be a field of characteristic p. We investigate the homotopy category K(Inj kG) of the category C(Inj kG) of complexes of injective (= projective) kG-modules. If G is a p-group, this category is equivalent to the derived category Ddg(C(BG; k)) of the cochains on the classifying space; if G is not a p-group it has better properties than this derived category. The ord...

in the present investigation, a novel adsorbent, ionic liquid modified magnetic nanoparticles (il-fe3o4), was successfully synthesized and characterized by ft-ir spectroscopy, thermogravimetric analysis (tga), xrd analysis, scanning electron microscopy (sem) and theory of brunauer, emmett, and teller (bet) for removal of reactive orange 122 (ro-122) from aqueous solutions. the effects of variou...

Hepatitis C virus (HCV) replication requires binding of the liver-specific microRNA (miRNA) miR-122 to two sites in the HCV 5' untranslated region (UTR). Although we and others have shown that viral genetics impact the amount of active miR-122 required for replication, it is unclear if HCV can replicate in the complete absence of this miRNA. To probe the absolute requirements for miR-122 and th...

OBJECTIVE To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected into HepG2 and huh7 cell lines which were then divided into six groups: miR...