Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imagin...

UNLABELLED Interleukin-13 Pseudomonas exotoxin (IL-13PE), a targeted agent for interleukin-13 receptor α2 (IL-13Rα2)-expressing tumors, has been administered intracranially by convection-enhanced delivery (CED) for glioma therapy in several clinical trials including a randomized phase 3 clinical trial. However, its intracranial distribution was not optimally evaluated. We investigated the intra...

Optical contrast agents have been widely applied to enhance the sensitivity and specificity of optical imaging with near-infrared (NIR) light. However, because of the overwhelming scattering of light in biological tissues, the spatial resolution of traditional optical imaging degrades drastically as the imaging depth increases. Here, for the first time to our knowledge, we present noninvasive p...

the objective of the present study was to evaluate the effect of metal mobilizing agents, ethelynediaminetetraacetic acid (edta) and salicylic acid (sa), on the accumulation and translocation of lead (pb) and nickel (ni) by fenugreek ( trigonellafoenum-graecum l . ) plants in contaminated soil. edta and sa were amended at 100 mm and 1.0 mm respectively. pb and ni content were estimated using ic...

Abstract Optical imaging involves the propagation of light through tissue. Current optical breast technologies, including diffuse spectroscopy, tomography, and photoacoustic imaging, capitalize on selective absorption in near-infrared spectrum by deoxygenated oxygenated hemoglobin. They provide information morphological functional characteristics different tissues based their varied interaction...

Islet amyloid deposition composed of amylin aggregates is regarded as one of the hallmarks of type 2 diabetes mellitus (T2DM). For the diagnosis of T2DM, several nuclear medical imaging probes have been developed. However, there have been no reports regarding the development of imaging probes targeting amylin. In this report, we investigated the feasibility of amylin imaging using [(125)I]IPBF ...

  Introduction: Data on imaging findings in pulmonary complications of chemical agents is scarce. The current study aimed to evaluate radiological findings of late onset pulmonary complications in chemical warfare victims (CWV) and to guide pulmonologists in diagnosis of these subjects.   Materials and Methods: Ninety- three male CWV were enrolled in this prospective study, 20-25 years (mean=23...

Gold nanoparticles with tunable absorption and scattering properties have been developed as contrast agents for various optical imaging techniques. As a hybrid modality that combines the merits of both optical and ultrasonic imaging, photoacoustic (PA) imaging also benefits from the use of these nanoparticles to greatly enhance the contrast for visualization of structures and biomarkers in biol...