PURPOSE To investigate the associations of single nucleotide polymorphisms (SNPs) of three genes (IL-12B, IL-12Rβ1 and IL-12Rβ2) in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS A total of 806 BD cases, 820 VKH patients, and 1600 healthy controls were involved in this study. The first investigation included 400 BD patients, 400 VKH cases, a...

of antimycobacterial drugs that are also effective against M. avium complex (4). In 2 studies that evaluated the effect of adjunctive IL-2 therapy in addition to ART for previously treatment-naive patients with HIV infection, baseline median numbers of circulating CD4+ cells increased significantly, but expansion of CD4+ T cells was not associated with the reduction in the risk for opportunisti...

T cell infiltration of melanoma is associated with enhanced clinical efficacy and is a desirable endpoint of immunotherapeutic vaccination. Infiltration is regulated, in part, by chemokine receptors and selectin ligands on the surface of tumor-specific lymphocytes. Therefore, we investigated the expression of two homing molecules--CXCR3 and CLA - on vaccine-induced CD8 T cells, in the context o...

abstractbackground: this study aimed to present a rare case of neu-laxova syndrome (nls) and review the newly revealed genetic features of the disease in hopes to find a way for early interventions.case report: female newborn with nls was born at 30 weeks of gestation to consanguineous parents. the last prenatal ultrasound imaging revealed severe intrauterine growth restriction and microcephaly...

in a survey carried out to establish the incidence of erythrocyte glucose­ 6-phosphate-dehydrogenase deficiency, 738 professional blood donors of tehran were examined. the fluorescent spot technique was used for screening and qualitative determination of g-6-pd in erythrocytes. this technique was compared with other methods of g-6-pd enzyme assay and proved to be very reliable. qualitative enzy...

trichuriasis is an intestinal parasitic disease which is caused by trichuris trichiura, a soil transmitted helminth. in order to evaluate the iron status of trichuriasis in patients a total of 120 (49 males and 71 females) cases with trichuris trichiura as well as 54 healthy individuals were evaluated. blood samples were analyzed for serum iron, transferrin saturation percent, haemoglobin and o...

the primary immunodeficiency (pi) disorders are abnormalities in development and maturation of the immune system. individuals with pi disease may experience frequent infections, which limit their abilities to exhibit physical and psychological well-being secondary to their illness. in this survey we compared health-related quality of life of primary immune deficient patients with healthy childr...

nutrition is an important factor that influences immunity, and nutritional deficiencies can impair resistance to infections. malnutrition is the most common cause of immunodeficiency worldwide. trace elements such as zinc, selenium, iron, and copper can influence several components of immunity. primary antibody deficiency disorders are a group of disorders characterized by an unusual susceptibi...

since early works on isolation and characterization of vitamin d by elmer verner mccollum and edward mellanby in 1900s, this molecule still seems mysterious (1-2). after several decades since discovery of the miraculous effect of cod liver oil in treatment of nutritional rickets, escalating number of reports provide a huge body of evidence for various effects of vitamin d on human body (3). the...