Mesenchymal stem cells are widely used in the treatment of many diseases, including osteoarthritis, due to their ability differentiate into cartilage. The high chondrogenic differentiation potential synovial fluid-derived mesenchymal increases importance these osteoarthritis treatments. Addition BMP-9 and TGF-ß3 medium, they also cause hypertrophic effects on chondrocytes. In our study, it was ...

In order to clarify how intra-articular lesions influence the survival of a periacetabular osteotomy in patients with dysplasia of the hip, we performed an observational study of 121 patients (121 hips) who underwent a transposition osteotomy of the acetabulum combined with an arthroscopy. Their mean age was 40.2 years (13 to 64) and the mean follow-up was 9.9 years (2 to 18). Labral and cartil...

BACKGROUND Osteopetrosis is an uncommon, inherited disease, characterized by osteosclerosis, obliteration of the medullary canal, calcified cartilage and brittle bone due to impaired osteoclast resorption. Osteoarthritis is common in patients with osteopetrosis. If the patient has pain and dysfunction, total joint arthroplasty is often the treatment of choice but presents many intraoperative an...

Hemophilic arthropathy is a progressive, disabling condition with poorly understood pathobiology. Since there is an emerging interest to study the role of intra-articular fat pad size and biology in arthritic conditions, we explored fat pad volume changes in hemophilic arthropathy and to what extent they differed from osteoarthritis. We matched a cohort of 13 adult patients with hemophilic arth...

introduction: knee joint osteoarthritis is one of the most prevalent musculoskeletal problems in adult population, which cause pain and functional limitations. involvement of medial compartment is almost 10 times more common than lateral compartment, which results in varus deformity among patients with medial compartment osteoarthritis of knee joint. main objectives in the treatment of knee joi...

knee osteoarthritis can have negative effects on the physical and mental conditions, social and family relations, general health and positive feelings of elders. for example, severe limitation of motion and increased depression, which are results of this disease, can have negative impacts on elders. the purpose of this study was to compare the levels of depression in healthy active and inactive...