Abstract Background and Aims Thrombotic microangiopathy without severe ADAMTS-13 deficiency activity levels (TMA-13n) has a high mortality rate. Early recognition of patients at higher risk dying or needing chronic renal replacement therapy (composite outcome: CO) become paramount importance since treatments such as eculizumab could ameliorate the prognosis this group patients. Plasmic score ha...

(13)N, generated by proton bombardment of (13)C powder, is rapidly and easily converted to (13)N-N(2), 0.01 atm pressure, ca. 10 mCi/ml, by automated Dumas combustion. (13)N fixed (as (13)N-N(2)) by algal filaments was localized by an autoradiographic technique which permits track autoradiography with isotopes having short half-lives. Our findings show directly that a minimum of about 25% of th...

The pathway of ammonia incorporation into amino acids was studied by use of 13N-ammonium ions in Bacillus megaterium and Escherichia coli that had been grown aerobically on a minimal salts medium containing NH4Cl as the source of nitrogen. Anion- and cation-exchange high-pressure-liquid chromatography was used to separate amino acids relevant to the several possible pathways for ammonia assimil...

BACKGROUND We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET). METHODS AND RESULTS Myocardial images were obtained after intravenous (18)F-fluorodeoxyglucose (18FDG) in 11 normal rats (group 1) and assembled into polar maps. Regional 18F activity concentration...

We consider a classical model known as bootstrap percolation on the n×n square grid. To each vertex of the grid we assign an initial state, infected or healthy, and then in consecutive rounds we infect every healthy vertex that has at least 2 already infected neighbours. We say that percolation occurs if the whole grid is eventually infected. In this paper, contributing to a recent series of ex...

Neutron yields and energy spectra have been measured for various deuteron-induced reactions at low energy. Neutrons of energy > 100 keV emitted in the 9Be(d,n)10B, 12C(d,n)13N, and 13C(d,n)14N reactions at Ed= 1.5 MeV were detected at five angles by means of liquid scintillator detectors. While low-energy neutrons were observed in all studied reactions, only 13C(d,n)14N is characterized by a re...

Development of Bruton’s tyrosine kinase (BTK) inhibitors is great value and significance in the treatment B-cell malignancies autoimmune diseases. Herein, a novel class pyrazolopyrimidine-based BTK were designed evaluated mantle cell lymphoma (MCL) lines. We demonstrated that target compounds had made progress improvement antiproliferative activity compared to lead compound. Compounds 13c, 13g,...