introduction:the use of beta emitters is one of the effective methods for palliation of bone metastasis. the risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. methods: in this study, the monte carlo simulation code mcnpx was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. specific absorbed fractions were calculated...

objective(s): this study describes the preparation, biodistribution of 153sm-dtpa-spion after intravenous injection in rats. materials and methods: the chelator dtpa dianhydride was conjugated to spion using a small modification of the well-known cyclic anhydride method. conjugation was done at a 1: 4 (spion: ccdtpa) molar ratio. conjugation reaction was purified with magnetic assorting column ...