Currie, Suzanne, Bruce L. Tufts, and Christopher D. Moyes. Influence of bioenergetic stress on heat shock protein gene expression in nucleated red blood cells of fish. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R990–R996, 1999.—The physiological and biochemical signals that induce stress protein (HSP) synthesis remain conjectural. In this study, we used the nucleated red bl...

NADES PALANIYAR,1 ROSS A. RIDSDALE,1 STEPHEN A. HEARN,2 YEW MENG HENG,3 F. PETER OTTENSMEYER,3 FRED POSSMAYER,4 AND GEORGE HARAUZ1 1Department of Molecular Biology and Genetics, University of Guelph, Guelph N1G 2W1; 2Department of Pathology, St. Joseph’s Health Center, London N6A 4L6; 3Division of Molecular and Structural Biology, Ontario Cancer Institute, and Department of Medical Biophysics, ...

Mack, David R., Sonia Michail, Shu Wei, Laura McDougall, and Michael A. Hollingsworth. Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G941–G950, 1999.—Probiotic agents, live microorganisms with beneficial effects for the host, may offer an alternative to conventional antimicrobia...

Farrell, Peter A., Mark J. Fedele, Thomas C. Vary, Scot R. Kimball, Charles H. Lang, and Leonard S. Jefferson. Regulation of protein synthesis after acute resistance exercise in diabetic rats. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E721–E727, 1999.—These studies determined whether insulin-like growth factor-I (IGF-I) involvement in exercise-stimulated anabolic processes becomes more evide...

BACKGROUND Pyrazinamide (PZA) is essential in tuberculosis treatment. We describe the prevalence, trends, and predictors of PZA resistance in Mycobacterium tuberculosis complex (MTBC) in the United States. METHODS We analyzed culture-positive MTBC cases with reported drug susceptibility tests for PZA in 38 jurisdictions routinely testing for PZA susceptibility from 1999 to 2009. National Tube...

The ability of various DNA damaging agents to induce asynchronous replication of polyoma DNA (APR) in rat cells carrying integrated copies of these DNA sequences may provide a useful model for understanding mechanisms of gene amplification. The present study has explored in detail the ability of UV irradiation to induce APR in the polyoma transformed rat fibroblast cell line H3. We have found t...

Sulphate assimilation provides reduced sulphur for the synthesis of cysteine, methionine, and numerous other essential metabolites and secondary compounds. The key step in the pathway is the reduction of activated sulphate, adenosine 5'-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR). In the present study, [(35)S]sulphur flux from external sulphate into glutathione (GSH) and...

The final project for this special topics class will be to read a paper or papers related to algebraic statistics, write a paper about what you read, and give a presentation to the class on the material. Students are encouraged to explore beyond their paper, i.e. try to come up with questions to think about related to the problem studied in the paper. Timeline: • Feb. 10: Choose paper. Send me ...

The sulphate assimilation pathway provides reduced sulphur for the synthesis of the amino acids cysteine and methionine. These are the essential building blocks of proteins and further sources of reduced sulphur for the synthesis of coenzymes and various secondary compounds. Several recent reports identified the adenosine 5'-phosphosulphate reductase (APR) as the enzyme with the greatest contro...

Wright, Carola E., F. Haddad, A. X. Qin, P. W. Bodell, and K. M. Baldwin. In vivo regulation of b-MHC gene in rodent heart: role of T3 and evidence for an upstream enhancer. Am. J. Physiol. 276 (Cell Physiol. 45): C883–C891, 1999.—Cardiac b-myosin heavy chain (b-MHC) gene expression is mainly regulated through transcriptional processes. Although these results are based primarily on in vitro cel...