The effects of 17 beta-estradiol on the proliferation and differentiation of cultured normal human bone marrow stromal cells were investigated. Treatment of 17 beta-estradiol at the concentration of 10(-6) approximately 10(-10) M for either 48 hours or 7 days did not affect [3H] thymidine incorporation. 17 beta-estradiol (10(-8)M) treatment for 4 or 7 days also failed to stimulate alkaline phos...

INTRODUCTION A national audit of waiting times in England's genitourinary medicine clinics measures patient access. Data are collected by patient questionnaires, which rely upon patients' recollection of first contact with health services, often several days previously. The aim of this study was to assess the accuracy of patient-reported waiting times. METHODS Data on true waiting times were ...

Abstract Backgroung: Recent studies have shown that Tramadol has local anesthetic effects in addition to its classical analgesic effect. In this study, the local anesthetic and postoperative analgesic effects of Tramadol were compared with those of Lidocaine in minor surgeries under local anesthesia. If the efficacy of Tramadol in this regard is proven, it will make considerable advances in th...

Purpose Data on aminoglycoside stewardship in critically ill septic patients with acute kidney injury (AKI) needing continuous renal replacement therapy (CRRT) are scarce. The objectives of the study were to determine, during CRRT, time window low likelihood for safe reinjection and proportion inappropriate reinjection. Methods A post hoc observational analysis a multicenter randomized trial co...

Abstract Aim NELA recommends rapid request, conduct and reporting of CT to reduce the delay in time theatre thus ultimately improving patient outcomes. Our aim was identify delays with regards scanning reporting. Methods Local Laparotomy Pathway standard that scans be performed within one hour being requested reported performed. data electronic records were reviewed over a 3 month period (Janua...

An individual's identification of his retirement situation does not necessarily coincide with the retirement concept as defined by objective measures. Self-evaluation of retirement status by respondents to the Retirement History Study has been analyzed to discover to what extent their subjective assessment of retirement matched the situation predicted by objective measures. For those completely...

A significant amount of economic activity takes place within the home. Unfortunately, it is difficult to assess the cyclical properties of home production because the available data are too sporadic. Using a Real Business Cycle model, we construct quarterly data on three variables that are unobservable at a quarterly frequency: hours worked in the home sector, hours spent in leisure, and the co...

Background and purpose - Immediate postoperative pain management offered in knee arthroplasty is suboptimal in up to one-third of patients resulting in high opiate consumption and delayed discharge. In this meta-analysis we investigate the analgesic effect and safety of perioperative adjuvant corticosteroids in knee arthroplasty. Methods - Databases Medline, Embase, and Central were searched fo...

BACKGROUND AND OBJECTIVES Hemorrhoidectomy may be performed under several anesthetic techniques and in outpatient regimen. Postoperative pain is severe and may delay discharge. This study aimed at evaluating bilateral pundendal nerves block for post- hemorrhoidectomy analgesia. METHODS Bilateral pundendal nerves block with 0.25% S75:R25 bupivacaine was performed with nerve stimulator in 35 pa...

The series on average hours worked in the manufacturing sector is a key leading indicator of the U.S. business cycle. The paper deals with robust estimation of the cyclical component for the seasonally adjusted time series. This is achieved by an unobserved components model featuring an irregular component that is represented by a Gaussian mixture with two components. The mixture aims at captur...