PURPOSE Intratumoral metabolic heterogeneity may increase the likelihood of treatment failure due to the presence of a subset of resistant tumor cells. Using a head and neck squamous cell carcinoma (HNSCC) xenograft model and a real-time fluorescence imaging approach, we tested the hypothesis that tumors are metabolically heterogeneous, and that tumor hypoxia alters patterns of glucose uptake w...

A variety of diacylglycerol (DG) molecular species are produced in stimulated cells. Conventional (α, βII and γ) and novel (δ, ε, η and θ) protein kinase C (PKC) isoforms are known to be activated by DG. However, a comprehensive analysis has not been performed. In this study, we analyzed activation of the PKC isozymes in the presence of 2-2000 mmol% 16:0/16:0-, 16:0/18:1-, 18:1/18:1-, 18:0/20:4...

Purpose To conduct a simplified lesion-detection task of low-dose (LD) PET-CT protocol for frequent lung screening using 30% the effective PETCT dose and to investigate feasibility increasing clinical value low-statistics scans machine learning. Methods We acquired 33 SD PET images, which 13 had actual LD (ALD) PET, simulated (SLD) images at seven different count levels from scans. employed ima...

Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [(99m)Tc(H2O)3(CO)3](+) complex. [(99m)Tc]-ECB-DG and [(99m)Tc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na(99m)TcO4 in 1 mL sa...

We consider the dg-category of twisted complexes over simplicial ringed spaces. It is clear that a map $$f:({\mathscr {U}},{\mathscr {R}})\rightarrow ({\mathscr {V}}, {\mathscr {S}})$$ between spaces induces dg-functor $$f^*:\mathrm{Tw}({\mathscr {S}})\rightarrow \mathrm{Tw}({\mathscr {U}}, {R}})$$ where $$\mathrm{Tw}({\mathscr denotes on $$({\mathscr . prove for homotopic maps f and g, there e...

Extensive efforts have recently been devoted to developing noninvasive imaging tools capable of delineating brain tissue viability (penumbra) during acute ischemic stroke. These efforts could have profound clinical implications for identifying patients who may benefit from tPA beyond the currently approved therapeutic time window and/or patients undergoing neuroendovascular treatments. To date,...