نتایج جستجو برای: 186re
تعداد نتایج: 57 فیلتر نتایج به سال:
UNLABELLED Several bone-seeking radionuclides (32P, 89Sr, 186Re, and 153Sm) have been used to treat bone pain. The limiting factor in this modality is marrow toxicity. Our hypothesis is that marrow toxicity can be reduced while maintaining therapeutic efficacy using radionuclides that emit short-range beta particles or conversion electrons (CEs). A recent study on 47 patients using the short-ra...
Introduction: The palliative care in patients with bone metastasis includes variety of techniques such as conventional analgesics, surgery, external beam radiotherapy, hormone therapy, chemotherapy and using bone-seeking radiopharmaceuticals. Even some of the recent works used combined methods like chemotherapy and radionuclide therapy or using radionuclide therapy as adjuvant ...
1027. 27. Brouwers AH, Mulders PF, de Mulder PH, van den Broek WJ, BuijsWC, Mala C, Joosten FB, Oosterwijk E, Boerman OC, Corstens FH,Oyen WJ. Lack of efficacy of two consecutive treatments of radio-immunotherapy with 131I-cG250 in patients with metastasizedclear cell renal cell carcinoma. J Clin Oncol 2005; 23: 6540-6548.(PMID: 16170161) 28. Gleave ME, Elhilali M, Fradet Y,...
It has been predicted that low affinity antibodies (Abs) should pen etrate into tumors more readily than high affinity Abs. However, the absolute uptake and residence time of a high affinity Ab may be better. It is, therefore, not clear whether a high affinity Ab would have a therapeutic advantage. This is particularly relevant with 125Iradioimmunotherapy, where targeting of every cell is impor...
The t r ihydroxamate bifunctional chelating agent (BCA), trisuccin, has been shown to be a potential ligand for radiolabeling of monoclonal antibodies (MAbs) with rhenium radioisotopes, through an indirect postconjugation approach. The use of this t r ihydroxamate BCA made it possible to prepare stable BCA-MAb conjugates in pure form that could be radiolabeled with carrier-free lSSRe. The antiT...
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