BACKGROUND The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is not fully understood. Moreover, relatively few studies have investigated the...

The differential diagnosis between recurrence of gliomas or brain metastases and this phenomenon is important in order to choose the best therapy and predict the prognosis but is still a big problem for physicians. The new emerging MRI, CT, and PET diagnostic modalities still lack sufficient accuracy. Radiolabeled choline and amino acids have been reported to show great tumor specificity. We st...

Prostate cancer (PCa) is one of the most common malignancies and main causes of cancer death in Western countries. In the presence of metastatic disease, systemic treatment remains the main clinical option. However, since the introduction of highly sensitive imaging techniques, a new clinical 'entity' of metastatic patients with a limited number of lesions has been defined: oligometastatic pati...

The glycerophospholipid phosphatidylcholine is the most abundant phospholipid species of eukaryotic membranes and essential for structural integrity and signaling function of cell membranes required for cancer cell growth. Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growt...

A 72-year-old patient was referred to our department to carry out an 18F-Choline PET–CT due to biochemical PSA failure from prostate cancer. The patient’s prostate cancer history started 5 years ago when he was diagnosed of a Gleason 3 + 4 tumor and treated with external radiotherapy. Three years later he presented biochemical failure and prostate tumor recurrence. Transrectal biopsy confirmed ...

When confronted with a suspicious rise in CA 15.3 in asymptomatic breast cancer patients following primary treatment and negative or equivocal conventional imaging findings, FDG PET/CT allows assessment of the site and extent of the recurring disease with an accuracy of 83%. Both FDG PET and FDG PET/CT are superior when compared to CT alone for the purpose of recurrence detection in patients su...

Background and PurposeThis pilot study aims to describe the advantages of combining metabolic anatomic imaging modalities in brachytherapy (BT) planning for locally advanced cervical cancer (LACC) evaluate supplementary value Fluoro(F)-Choline positron emission tomography/computed tomography (PET/CT) comparison 18F-fluorodeoxyglucose (FDG) this setting.Materials MethodsA prospective cohort six ...

Introduction: 18F-Choline PET-CT is an increasingly used technique in patients with prostate cancer. The main indication is to localise the disease in patients with biochemical recurrence. To accurately interpret 18F-Choline PET, knowledge of normal tracer distribution is paramount. The aim of this study was to describe the normal distribution pattern of 18F-Cho...

PET/MRI is a new hybrid imaging modality and has the potential to become a powerful imaging tool. It is currently one of the most active areas of research in diagnostic imaging. The characterisation of an incidental renal lesion can be difficult. In particular, the differentiation of an oncocytoma from other solid renal lesions such as renal cell carcinoma (RCC) represents a diagnostic challeng...