conclusions in this study, phylogenetic reconstruction of hcv-1 sequences clearly indicated for molecular tracing and ancestral relationships of the hcv genotypes in iran, and showed the likelihood of domestic origin for hcv-1a and various origin for hcv-1b. evidence acquisition the phylogenetic analyses were performed based on the nucleotide sequences of ns5b gene of hcv genotype 1 (hcv-1), wh...

We previously reported that insulin sensitivity was increased in vasopressin V(1B) receptor-deficient (V(1B)R(-/-)) mice. Here, we investigate the lipid metabolism in V(1B)R(-/-) mice. Despite having lower body weight, V(1B)R(-/-) mice had significantly greater fat weight of the epididymal white adipose tissue than V(1B)R(+/+) mice. Glycerol production and beta-oxidation were suppressed in V(1B...

Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking all established and predicted mouse Oatp1a/1b transporters (referred to as Slco1a/1b-/- mice, as SLCO genes encode OATPs). Slco1a/1b-/- mice were ...

Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus). The deduced amino acid sequences share greater similarity with mammalian UGT1 family genes than UGT2 genes (...

In the search for genes expressed in hematopoietic stem cells, we identified that the expression of Gfi-1B (growth factor independence-1B) is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Gfi-1 and Gfi-1B are zinc finger proteins that share highly conserved SNAG and 6 zinc finger domains. Gfi-1 has been characterized as an oncogene involved in lymphoid malign...

Aim: To examine the role of cytokine interleukin-1b (IL-1b) in retinal capillary cell death in diabetes. Methods: The effect of glucose on the expression of IL-1b was measured in the bovine retinal endothelial cells. The role of IL-1b in the accelerated endothelial cell loss was determined by investigating the effect of human recombinant IL-1b on their apoptosis in normal and high glucose condi...

Myelin-associated glycoprotein (MAG) is expressed in periaxonal membranes of myelinating glia where it is believed to function in glia-axon interactions by binding to a component of the axolemma. Experiments involving Western blot overlay and coimmunoprecipitation demonstrated that MAG binds to a phosphorylated neuronal isoform of microtubule-associated protein 1B (MAP1B) expressed in dorsal ro...

This work investigated the microstructure and elevated-temperature (400-475C) tensile and tensile-creep deformation behavior of a powder metallurgy (PM) rolled Ti-6Al-4V-1B(wt.%) alloy. The PM rolled Ti-6Al-4V-1B alloy exhibited a duplex microstructure, and it did not exhibit a strong α-phase texture compared with the PM extruded Ti-6Al-4V-1B alloy. The PM rolled Ti6Al-4V-1B alloy exhibited gre...

Marek's disease virus (MDV) is an oncogenic alphaherpesvirus that is highly contagious in poultry. Recombinant RB-1B (rRB-1B) reconstituted from an infectious genome cloned as a bacterial artificial chromosome (BAC) is unable to spread horizontally, quite in contrast to parental RB-1B. This finding suggests the presence of one or several mutations in cloned relative to parental viral DNA. Seque...

OBJECTIVE To examine the long-term impact of early treatment initiation of interferon beta-1b (IFNB1b, Betaferon/Betaseron) in patients with a first event suggestive of multiple sclerosis (MS). METHODS In the original placebo-controlled phase of BENEFIT, patients were randomised to IFNB1b 250 μg or placebo subcutaneously every other day. After 2 years or diagnosis of clinically definite MS (C...