BACKGROUND Increased levels of interferon (IFN)-inducible IFI16 protein (encoded by the IFI16 gene located at 1q22) in human normal prostate epithelial cells and diploid fibroblasts (HDFs) are associated with the onset of cellular senescence. However, the molecular mechanisms by which the IFI16 protein contributes to cellular senescence-associated cell growth arrest remain to be elucidated. Her...

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumours with various clinical characteristics. These tumours generally exhibit complex karyotypes. Few studies of genomic imbalances have been performed exclusively in subgroups of larynx cancer samples at different stages of the disease. In the present study, chromosomal gains and losses were investigated in 52 larynx tu...

BACKGROUND Three recent genome-wide association studies (GWASs) have reported that three SNPs (rs4072037, rs13361707 and rs2274223) located on genes related to host inflammatory response are significantly associated with susceptibility to gastric cancer (GC) in Chinese populations. Helicobacter pylori infection is also an important risk factor for GC through causing inflammatory response in the...

BACKGROUND Genomic aberration is a common feature of human cancers and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of tumor suppressor genes. Our study aims to identify frequent genomic changes in pancreatic cancer. MATERIALS AND METHODS We used array comparative genomic hybridization (array CGH) to identify recurrent genomic alterations an...

OBJECTIVE Although several genome-wide association studies (GWAS) of non-cardia gastric cancer have been published, more novel association signals could be exploited by combining individual studies together, which will further elucidate the genetic susceptibility of non-cardia gastric cancer. DESIGN We conducted a meta-analysis of two published Chinese GWAS studies (2031 non-cardia gastric ca...

FAMILIAL NONMEDULLARY THYROID CANCER (Abstract): Follicular cell-derived thyroid cancer which represents 90-95% of all thyroid malignancies may occur in at least 5% of cases as familial disease. Familial nonmedullary thyroid cancer (FNMTC) is defined as the existence of two or more first degree relatives affected within a family. FNMTC may occur in two situations: pure FNMTC in which FNMTC is t...

Basal cell carcinomas, the most common human tumors, generally appear sporadically and in small numbers. Rarely, they may appear in great numbers and at an earlier age as a manifestation of the basal cell nevus syndrome, an autosomal dominant inherited disorder. Drawing on the retinoblastoma paradigm, we have begun a search for tumor suppressor genes important in the development of basal cell c...

Abstract The proband was patient A2, suffering by severe left ventricular dysfunction (EF 20%) and II degree Mobitz type 1 atrioventricular block, requiring dual chamber ICD implantation, retinitis pigmentosa. He had three brothers A1, A4, A5 also dilated cardiomyopathy ICD/CRTD recipients. His sister A3, his daughter B1 the firstborn brother A1 were affected Genetic analysis performed in A2 NG...

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