BACKGROUND The South African (SA) health system has employed an Essential Medicines List (EML) with Standard Treatment Guidelines (STGs) since 1996. To date no studies have reported the changes in SA STG/EMLs. This study describes these changes over time (1996-2013) and compares latest SA STG/EMLs with the latest World Health Organization (WHO) Model EMLs to assess alignment of these lists. M...

Peptide ligand-induced dimerization of the extracellular region of the epidermal growth factor receptor (sEGFR) is central to the signal transduction of many cellular processes. A small molecule microarray screen has been developed to search for non-peptide compounds able to bind to sEGFR. We describe the discovery of nitro-benzoxadiazole (NBD) compounds that enhance tyrosine phosphorylation of...

BACKGROUND Reduced sensitivity to positive feedback is common in patients with major depressive disorder (MDD). However, findings regarding negative feedback are ambiguous, with both exaggerated and blunted responses being reported. The ventral striatum (VS) plays a major role in processing valenced feedback, and previous imaging studies have shown that the locus of controls (self agency v. ext...

Solanum asterophorum Mart. (Solanaceae) is a shrub popularly known as "jurubeba-defogo" in the northeast of Brazil. In the present work, the methanol extract (SA-MeOH, 3750 microg/mL) and isojuripidine (10(-7) - 3 x 10(-4) M), a steroidal alkaloid obtained from S. asterophorum Mart. leaves, inhibited phasic contractions induced by both 1 microM histamine [IC50 = (225.8 +/- 47.4), g/mL and (3.5 ...

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SA HealthPlus is a trial of coordinated care enrolling 4000 high-use patients in South Australia in 10 groups including diabetes, cardiac, aged care and lung disease. These patients each have a designated general practitioner (GP) care coordinator who formulates an individualized care plan designed to keep them as healthy as possible. An on-line interface to SA HealthPlus has been developed for...

A classical result of Arnold and Brieskorn [Bk], [Bk2] states that the complement of the discriminant of the versal unfolding of a simple hypersurface singularity is a K(π, 1). Deligne [Dg] showed this result could be placed in the general framework by proving that the complement of an arrangement of reflecting hyperplanes for a Coxeter group is again a K(π, 1) (and more generally for simplicia...

1998 2 To Marceline 4 Acknowledgements Many dear people have either deeply aaected my way through these last years of studies, or actively helped in my research work (some of them did both); I would like to thank them. First of all, I would like to thank my parents who have always supported and encouraged me, even in my decision to spend time abroad-a decision that certainly weighted on them. I...

BACKGROUND Tuberculosis (TB) is still a leading cause of death worldwide. Almost a third of the world's population is infected with TB bacilli, and each year approximately 8 million people develop active TB and 2 million die as a result. Today's TB treatment, which dates back to the 1970s, is long and burdensome, requiring at least 6 mo of multidrug chemotherapy. The situation is further compou...

Cellular prion protein (PrP(c)), the normal isoform of the pathogenic peptide (PrP(sc)) responsible of the transmissible spongiform encephalopaties (TSEs), is present in many neural tissues, including neuromuscular junctions (NMJ). To analyze if this protein could influence the synaptic transmission, we performed an electrophysiological approach to study the effect of cellular prion protein on ...