The apoptotic effects of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 2-aminophenoxazine-3-one (Phx-3) on human glioblastoma cell lines, A-172 and U-251 MG were studied. These phenoxazines extensively decreased the viability of A-172 and U-251 MG cells (IC50 of Phx-1: 60 microM, in both lines; IC50 of Phx-3: 10 and 3 microM, for A-172 and U-251 cells, respectivel...

Glomerular mesangial cells (MC) play a central role in the synthesis and turnover of the glomerular extracellular matrix. Prior studies [Davies, Thomas, Martin and Lovett (1988) Biochem. J. 251, 419-425; Martin, Davies, Thomas and Lovett (1989) Kidney Int. 36, 790-801] have characterized at the protein level a 72 kDa type IV collagenase that is secreted by cultured human and rat MC. While expos...

Thomas Andrews (1813-1885) performed important research in the area of thermochemistry, thermodynamics of phase equilibrium, and the nature and properties of ozone. His work on the heat of reaction between acids and bases is notable for its high technique and good numerical results, in spite of having been done at the time before the advent of the Arrhenius theory and when the law of conservati...

The following paper attempts to discuss the connection between meaning and use in language by examining how we can speak of sharing and not sharing with others. As an introduction to this theme a passage is presented and discussed from Raimond Gaita‟s book A common humanity: thinking about love truth and justice, in which he speaks of the importance of other human beings. This subject of others...

most jarring during his discussion on the two pandemics so far this century, SARS and swine flu. When discussing SARS, he describes media coverage as ‘alarmist’, suggests that public health workers used the outbreak to demonstrate that their field was still relevant, and claims that firm actions by governments, such as imposing quarantine and closing schools, were more about restoring the confi...

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Inactivation of the retinoblastoma (Rb) tumor suppressor protein is widespread in human cancers. Inactivation of Rb is thought to be initiated by association with Raf-1 (C-Raf) kinase, and here we determined how RRD-251, a disruptor of the Rb-Raf-1 interaction, affects pancreatic tumor progression. Assessment of phospho-Rb levels in resected human pancreatic tumor specimens by immunohistochemis...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Orlova N, Riga O. 24-hour urinary free cortisol in children with paralytic syndromes and chronic pain. Pediatria Polska - Polish Journal of Paediatrics. 2021;96(4):245-251. doi:10.5114/polp.2021.112398. APA Orlova, N., & Riga, (2021). Paediatrics, 96(4), 245-251. https://doi.org/10.5114/polp.2021.112398 Chicago Na...