Abstract Background and Aims Analysis of the pathogenetic mechanisms development contrast nephropathy in patients with coronary artery disease on background type 2 diabetes mellitus effectiveness proposed preventive measures. Method The study included 56 diabetes, average age was 58 years, CG consisted 20 healthy persons. In most patients, reason for which endovascular radiopaque procedure (EVR...

1. Scagliotti GV, Bondarenko I, Blackhall F et al. Randomized, phase III trial of figitumumab in combination with erlotinib versus erlotinib alone in patients with non-adenocarcinoma nonsmall-cell lung cancer. Ann Oncol 2015; 26: 497–504. 2. Guix M, Faber AC, Wang SE et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin...

To search for unique mutations in the apolipoprotein B (apoB) gene that disrupt the binding of LDL to its receptor and cause hypercholesterolemia, we examined more than 800 patients with high LDL cholesterol levels and/or coronary artery disease (CAD). Analysis of patient DNA by single-strand conformation polymorphism and allele-specific oligonucleotide hybridization of the sequence surrounding...

OBJECTIVE Barriers to executing large-scale randomized controlled trials include costs, complexity, and regulatory requirements. We hypothesized that source document verification (SDV) via remote electronic monitoring is feasible. METHODS Five hospitals from two NIH sponsored networks provided remote electronic access to study monitors. We evaluated pre-visit remote SDV compared to traditiona...

This study investigated the evolution of physical and technical performances in the English Premier League (EPL), with special reference to league ranking. Match performance observations (n = 14,700) were collected using a multiple-camera computerised tracking system across seven consecutive EPL seasons (2006-07 to 2012-13). Final league rankings were classified into Tiers: (A) 1st-4th ranking ...

The platelet-derived neutrophil-activating peptide 2 (NAP-2, 70 amino acids) belongs to the ELR1 CXC subfamily of chemokines. Similar to other members of this group, such as IL-8, NAP-2 activates chemotaxis and degranulation in neutrophils (polymorphonuclear [PMN]) through chemokine receptors CXCR-1 and CXCR-2. However, platelets do not secrete NAP-2 as an active chemokine but as the C-terminal...

PURPOSE High protein intake in infancy has been linked to obesity. We aimed to examine the associations of protein intake in early childhood with cardiovascular and metabolic outcomes at school age. METHODS This study was performed in 2965 children participating in a population-based prospective cohort study. Protein intake at 1 year was assessed with a food frequency questionnaire and was ad...

The studbook of the Spanish Arab Horse was analysed in order to assess the available genetic variability in the population via genealogical analyses and to ascertain the influence of different countries in the formation of the population. The Spanish Arab horse studbook could be traced back to the late 19th century with a total of 18,880 animals. A 15.7% (2965) of the registered individuals wer...