Abstract Since its identification, IL-2 has been tested as a therapy for both oncology and autoimmunity it the ability to expand effector T cells NK well regulatory (Tregs). Due toxicity, focus of molecular engineering improve therapeutic properties index. To target CD4+CD25− CD8+CD25− cells, we rationally designed murine human variant bind IL-2Rβγ (IL2Rbg) heterodimer without binding IL-2Rα (I...

The mechanisms of how Th cells promote CD8(+) T cell responses during viral infections are largely unknown. In this study, we unraveled the mechanisms of T cell help for CD8(+) T cell responses during vaccinia virus infection. Our results demonstrate that Th cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activ...

Thymic Foxp3-expressing regulatory T cells are activated by peripheral self-antigen to increase their suppressive function, and a fraction of these cells survive as memory regulatory T cells (mTregs). mTregs persist in nonlymphoid tissue after cessation of Ag expression and have enhanced capacity to suppress tissue-specific autoimmunity. In this study, we show that murine mTregs express specifi...

Background: Systemic Lupus Erythematosus (SLE) is the prototype for a systemic autoimmune disease. SLE disease of adaptive immune system where T lymphocyte dysfunction has an important role as well. Checkpoint proteins have become topic in study Tcell. The balance cell co-stimulatory and co-inhibitory receptors regulation response. Objectives: In this we aimed to assess checkpoint childhood pat...

The abbreviations used are: MMTV, mouse mammary tumor virus; LTR, long terminal repeat; SATB1, special AT-rich binding protein 1; CDP, CCAAT-displacement protein; NRE, negative regulatory element; NURD, nucleosome remodeling and deacetylase complex; CHRAC, chromatin-accessibility complex; ACF, ATP-utilizing chromatin assembly and remodeling factor; YY1, ying-yang 1; GFP, green fluorescent prote...

B cell non-Hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis C virus (HCV) infection. The mechanism by which HCV infection leads to lymphoproliferative disorder remains unclear. Our group established HCV transgenic mice that expressed the full HCV genome in B cells (RzCD19Cre mice). We observed a 25.0% incidence of diffuse large B cell non-Hodgkin lym...