PURPOSE To examine the safety and tolerability of rapidly initiating adjunctive lacosamide via a single intravenous loading dose followed by twice-daily oral lacosamide in lacosamide-naive adults with partial-onset seizures. METHODS This open-label, multicenter trial, enrolled patients with epilepsy who were taking 1-2 antiepileptic drugs (AEDs) in one of four sequential cohorts containing 25...

BACKGROUND Despite being present in up to 1% of the population, few controlled trials have examined the efficacy of treatments for bipolar II depression. Pooled data are presented from four placebo-controlled studies (BOLDER I [5077US/0049] and II [D1447C00135]; EMBOLDEN I [D1447C00001] and II [D1447C00134]) that evaluated the efficacy of quetiapine monotherapy for depressive episodes in patien...

La Biblioteca Digital de la Universidad de Castilla-La Mancha pretende ser ofrecer todas las posibilidades de una biblioteca tradicional, tanto en cuanto a recursos como a servicios, y no quedarse en una mera colección de textos accesibles pero desorganizados. Se presenta esta biblioteca desde su gestación hasta el momento actual mostrando las posibilidades que ofrece y la experiencia de su pue...

• Potential living donors should have their urinary protein excretion measured using either a 24-hour urine collection (daily excretion) or a spot urine sample (protein/creatinine ratio). • A urine protein excretion of >300 mg/day (24 hour collection) or of >30 mg/mmol (spot urine protein/ creatinine ratio) is usually a contraindication to live donation. • Further investigations are warranted w...

This study of analgesic hepatotoxicity was conducted on rabbit divided into four equal groups (A—D). The group “A” served as control. The group “B” animals were administered acetylsalicylic acid (600 mg/Kg/day) orally,while group “C” animals received paracetamol (300 mg/Kg/day). The group “D” was given both the acetylsalicylic acid (300 mg/Kg/day) and paracetamol (150 mg/Kg/day). An autopsy was...

Epidemiological evidence supports comorbidity of generalized anxiety disorder (GAD) and major depressive disorder (MDD) or dysthymia, and its association with significant disability. As pregabalin, a new alpha(2)-delta anxiolytic treatment for GAD, unlike most other licensed treatments for GAD has not undergone investigation in patients with MDD, we examined its efficacy in depressive symptoms ...

Objectives: to evaluate efficacy and tolerability of two different dosages of eperisone (150 and 300 mg/day) in comparison with those of diazepam 15 mg/day, orally given for seven days. Methods: Spontaneous and provoked pain, muscular contracture and its impact on working capacity as well as “hand-to-floor” distance and degree of lumbar tract flexion were assessed in a randomised double-blind t...

The recent development by Casio of the hand-held ClassPad 300 device raises a number of important questions for the design of mathematical learning experiences for students. This paper provides a brief description of the ClassPad 300 and its mathematical capabilities, followed by a description of the idea of an eActivity, well provided for in the operating system of the device. As their name su...