LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant infi...

We present the Spitzer Space Telescope InfraRed Array Camera (IRAC) and Multiband Imaging Photometer (MIPS) observations of the elliptical galaxy NGC 315. After removal of the host galaxy’s stellar emission, we detected for the first time an infrared-red nucleus in NGC 315. We measured the spectral energy distribution (SED) for this active nucleus with wavelength range covering from radio to X-...

The murine myeloma MOPC-315 secretes a paraprotein which binds dinitrophenylated compounds. Maturational sub sets which mimic normal B-cell differentiation were shown to exist within this monoclonal neoplasm. The maturational sub sets were defined by an in vivo stem cell activity (plasmacytoma colony-forming unit-spleen), DMA synthesis ([3H]thymidine in corporation), membrane-bound paraprotein,...

A basic assumption of Jerne's network theory (1) is that the immune system of an individual can recognize its own antigen receptors. Because this concept opens many possibilities for immunological manipulation (2), it is important to ascertain whether the immune system recognizes its own immunoglobulin (Ig) variable (V) 1 domains in a way that conforms to the experience gained with conventional...

3. The “Nighttime Map” produced by the Census Bureau uses dots to depict population density according to the 2000 decennial census. Go to: http://www.census.gov/geo/www/mapGallery/2kpopden.html Suppose the Bureau instead made a histogram map, where each census tract was shaded according to its population density. What information about the U.S. population density would be gained in making this ...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Alcocer-Salas M, Santiago-Benitez MJ, Zepeda-Torres JM. Late onset non-familiar acrokeratosis verruciformis of Hopf. Dermatology Review/Przegląd Dermatologiczny. 2022;109(4):310-315. doi:10.5114/dr.2022.123986. APA Alcocer-Salas, M., Santiago-Benitez, M. J., & Zepeda-Torres, J. (2022). Dermatologiczny, 109(4), 310...

The trichomonad species Tritrichomonas foetus and Pentatrichomonas hominis were recently detected in the feces of dogs with diarrhea. However, little information is available on the prevalence and pathogenicity of these parasites in the canine population. Therefore, the aim of this study was to determine the prevalence and molecular characterization of trichomonads infecting pet dogs in Anhui a...

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In this study, we show that administration of low-dose melphalan (l -PAM, l -phenylalanine mustard) to mice bearing a large MOPC-315 plasmacytoma led to a rapid up-regulation of B7-1 (CD80), but not B7-2 (CD86), expression on the surface of MOPC-315 tumor cells. This l -PAM-induced preferential up-regulation of B7-1 surface expression was due, at least in part, to a direct effect of l -PAM on t...