Foldover is a widely used procedure for selecting follow-up experimental runs. As foldover designs require twice as many runs as the initial design, they can be inefficient if the number of effects to be dealiased is smaller than the size of the original experiment. Semifolding refers to adding half of a foldover fraction and is a technique that has been investigated in recent literature for re...

Aim: In the present study, the main objective was to develop a multiparticulate system containing chitosan microspheres for colon-specific drug delivery of capecitabine for the treatment of colorectal cancer. Materials and Methods: This study was based on the microbial degradability of chitosan microspheres. The microspheres were prepared with chitosan by emulsion cross linking method. A factor...

Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The O...

State University of New York at Stony Brook 2A two-level factorial design can be uniquely represented by a polynomial indicator function. Therefore, properties of factorial designs can be studied through their indicator functions. This paper shows that indicator function is an effective tool in studying two-level factorial designs. Indicator function is used to generalize aberration criterion o...

recently full factorial design approach has been used to assess the recycling potential of a given waste. the objective of this study is to identify the significant factors and interactions involved in maximizing compressive strength of concrete when chromium waste is used as admixture. in this respect, experimental factors at two levels, which are admixture type (chromite/ chromite+ superplas...

As final attributes of dosage form largely depend on the properties excipients used, understanding effect physicochemical is important. In present study, six grades L-HPC with varying degrees particle size and hydroxypropyl content influence grade compaction as well disintegration behavior were studied. All compressed at different compression loads to achieve tablet porosity. Compressibility co...