Background: This study aims to evaluate the effect of preoperative psychological intervention on the prevalence of early Postoperative Cognitive Dysfunction (POCD) in patients undergoing Off-Pump Coronary Artery Bypass Surgery (OPCAB). Materials and methods: Two groups of 1:1 paired patients (34 cases each) who underwent selective OPCAB were enrolled. One group received targeted preoperative ps...

MRX34, a microRNA (miRNA)-based therapy for cancer, has recently entered clinical trials as the first clinical candidate in its class. It is a liposomal nanoparticle loaded with a synthetic mimic of the tumor suppressor miRNA miR-34a as the active pharmaceutical ingredient. To understand the pharmacokinetic properties of the drug and to rationalize an optimal dosing regimen in the clinic, a met...

OBJECTIVES To describe the signalment, presence of systemic and/or ocular comorbidities, times to detected healing and probabilities of recurrence after diamond burr debridement (DBD) of eyes with presumed corneal calcareous degeneration and secondary ulceration and/or ocular pain. ANIMALS STUDIED Twenty-six dogs with 42 eyes affected, 34 eyes treated with DBD. METHODS A case series was con...

Introduction: The impact history of the solar system remains controversial. Early investigation of lunar samples, returned by Apollo astronauts, led to the 'Late Heavy Bombardment' (LHB) concept [1,2] which hypothesized a sharp increase in bolide flux centered around ~3.9 Ga. Evidence for this cataclysm was first derived from whole-rock U-Pb and Rb-Sr ages [2] but subsequently more on 40 Ar-39 ...

A generalized-ensemble technique, multicanonical sampling, is used to study the folding of a 34-residue human parathyroid hormone fragment. An all-atom model of the peptide is employed and the protein-solvent interactions are approximated by an implicit solvent. Our results demonstrate that generalized-ensemble simulations are well suited to sample low-energy structures of such large polypeptid...