CONTEXT Prolonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans. OBJECTIVE To examine the effects of 6 months of calorie restriction, with or without exercise, in overweight, ...

background: in conventional radiation therapy, regarding normal tissue tolerance, the treatment of bulk tumors is one of the remaining challenges. grid radiation therapy (grt) is a technique to deliver high doses, approximately 15 – 20 gy per fraction, to several small volumes located in a large radiation field. this can be performed using a grid block. the current work has concentrated on the ...

OBJECTIVE To investigate estimation of calorie (energy) content of meals from fast food restaurants in adults, adolescents, and school age children. DESIGN Cross sectional study of repeated visits to fast food restaurant chains. SETTING 89 fast food restaurants in four cities in New England, United States: McDonald's, Burger King, Subway, Wendy's, KFC, Dunkin' Donuts. PARTICIPANTS 1877 ad...

Efflux-mediated macrolide resistance due to mef(E) and mel, carried by the mega element, is common in Streptococcus pneumoniae, for which it was originally characterized, but it is rare in Streptococcus pyogenes In S. pyogenes, mega was previously found to be enclosed in Tn2009, a composite genetic element of the Tn916 family containing tet(M) and conferring erythromycin and tetracycline resist...

The dilatations that occur in the body are classified according to different systems: (1) biliary: mega-gallbladder, mega-common bile duct; (2) cardiovascular: cardiomegaly; (3) urinary: megapelvis, megaureter, megabladder; (4) respiratory: bronchiectasis, megabronchus; (5) megapharynx (?); (6) megaesophagus; (7) megastomach; (8) achalasia of the pylorus or hypertrophic pyloric stenosis; (9) me...

The MEGA microlensing survey is introduced and several topics about variable stars in M31 are discussed. An adopted model population of semiregular (SR) variable stars is presented, and the efficiency to recover these stars in M31 in a specific example MEGA dataset is predicted. The period-flux amplitude relation of the SRs discovered by MEGA could be used to measure the inclination of the M31 ...

Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly universal effect, little is understood about the molecular mechanisms that mediate the life-span-extending effect of calorie restriction in metazoans. Sir2 is known to be involved in life span determination and calorie restriction in yeast mother...

Calorie restriction (CR), which usually refers to a 20-40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the di...

This study examined the effect of housing density on the longevity-extending and disease-delaying actions of calorie restriction (CR). Singly or multiply housed (four per cage) mice were either fed ad libitum (AL) or were on CR beginning at 2 months. All CR mice were fed 40% less food than were multiply housed AL mice. CR increased median longevity by 19%, and housing density had no effect on t...

385 Aneurysmal dilation of AVF is due to the complex interplay between biologic factors like needle injury that induce outward wall remodeling, and physical factors such as wall tension that is directly proportional to intraaccess pressures. In a series of patients who underwent minimally invasive limited ligation endoluminal-assisted revision banding, pressure within the mid-fistula was reduce...