The title compound, C(18)H(27)N(3)O, is a derivative of the anti-tuberculosis drug isoniazid (systematic name: pyridine-4-carbohydrazidei). The crystal structure consists of repeating C(4) chains along the b axis, formed by N-H⋯O hydrogen bonds with adjacent amide functional groups that are related by a b-glide plane. The cyclo-dodecyl ring has the same approximately 'square' conformation, as s...

Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylic acid 3 is prepared by PPA-catalyzed thermal lactamization of the respective 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylic acid 9. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionic acid with 7-chloro-1-cyclo...

The mol-ecule of the title compound, C(12)H(10)N(4)O(4), displays an E configuration about the C=N bond. The dihedral angle between the benzene and isoxazole rings is 1.36 (5)° and the mol-ecular conformation is stabilized by the an intra-molecular C-H⋯N hydrogen bond. In the crystal structure, centrosymmetrically related mol-ecules are connected by pairs of N-H⋯O hydrogen bonds into dimers, wh...