نتایج جستجو برای: 410 a stellatus
تعداد نتایج: 13433164 فیلتر نتایج به سال:
Numerous studies confirmed that aberrant miRNAs expression contributes to multiple myeloma (MM) development and progression. However, the roles of specific miRNAs in MM remain to be investigated. In present study, we demonstrated that miR-410 expression was increased in MM newly diagnosed and relapsed tissues and cell lines. Clinical analysis revealed that miR-410 was positively correlated with...
FHL1 is an important tumor-suppressor that is downregulated in multiple tumors by unknown mechanisms. We demonstrated that miR-410 specifically targets the 3'UTR of FHL1. Furthermore, using DNA bisulfite modification and sequencing experiments, we demonstrated that the FHL1 promoter is hypermethylated in cancer cells. FHL1 methylation is increased upon miR-410 expression, suggesting that the re...
SLC34A2 had been reported to be down-regulated in human NSCLC cells and patient tissues, and played a significant role in lung cancer. However, the mechanism of its unusual expressionin NSCLC has not been fully elucidated. In present study, we identified SLC34A2 was a direct target of miR-410 and could be inhibited by miR-410 transcriptionally and post-transcriptionally. MiR-410 promoted the gr...
Our previous research indicated miR-410 played a critical role in promoting the tumorigenesis and development of NSCLC (non-small cells lung cancer). MiR-410 has been recently reported to be crucial for development and differentiation of embryonic stem cells. But it remains elusive whether miR-410 stimulates the stemness of cancer until now. Herein, we identify miR-410 induces the stemness and ...
Hibiscadelphus stellatus H. Oppenheimer, Bustamente, & Perlman, sp. nov., a new, narrowly endemic species from West Maui, Hawaiian Islands is described, illustrated and its affinities and conservation status are discussed. It is currently known from three populations totaling 99 plants in Kaua`ula valley on leeward western Maui. It differs from H. wilderianus, its nearest congener, in its dense...
Gastric cancer is one of the most frequent malignancies in tumors in the East Asian countries. Identifying precise prognostic markers and effective therapeutic targets is important in the treatment of gastric cancer. microRNAs (miRNAs) play important roles in tumorigenesis. However, the mechanisms by which miRNAs regulate gastric cancer metastasis remain poorly understood. In this study, we fou...
Osteosarcoma, which is the most common type of primary bone tumor in adolescents, is characterized by complex genetic alterations and frequent resistance to conventional treatments. MicroRNAs (miRs) have emerged as fundamental regulators in gene expression through their ability to silence gene expression at post-transcriptional and translational levels. The present study investigated the role o...
به منظور شناسایی جمعیت گاوماهی بچه قورباغه ای در محدوده آب های استان گیلان، پنج ایستگاه (آستارا، انزلی، کیاشهر، هشتپر و چابکسر) انتخاب شد. اکثر نمونه های صید شده در عمق 15-3 متری مشاهده شدند. فراوانی این گونه در ایستگاه بندر انزلی 41/0 درصد، در ایستگاه چابکسر 24/2 درصد و در ایستگاه آستارا 59/2 درصد از کل ماهیان صید شده گزارش شد و در ایستگاه های هشتپر و بندر کیاشهر مشاهده نشد. بر اساس نتایج به د...
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