est, because the biologically effective chiral drug is either of enantiomers and the antipode is regarded as the impurity showing sometime high toxicity. Recently, the HPLC with chiral stationary phases (CSPs) has been extensively used to achieve the direct enantiomer separation. Crown ether, first introduced by Pedersen in 1967, was shown by Cram et al. to resolve enantiomers by the host-guest...

A skin-associated population of memory T lymphocytes, defined by expression of the cutaneous lymphocyte antigen (CLA), binds selectively and avidly to the vascular lectin endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation. Here we present evidence that CLA itself is the (or a) lymph...

The hydrous species geospeedometer is based on the homogeneous interconversion reaction between molecular H2O species and OH species in silicate melts and glasses. Here we report new data for the calibration of the geospeedometer in rhyolitic glass, extending the coverage of quench rate to 94 K/s and of H2Ot to 7.7 wt.% by using a piston-cylinder apparatus at low pressures (200–500 MPa) to prev...

Purpose : A new method of calibration of the displacement of the cornea1 reflex in relation to the angular deviation was carried out on a population of normal subjects. Methods : The position of the cornea1 reflex was studied in 15 normal adult subjects, emmetropic and orthophoric. Each eye, photographed individually, was situated perpendicularly at the zero of a tangential scale. Slides taken ...

Fission yeast cells depend on the anillin-related protein Mid1p for reliable cytokinesis. Insolubility limits the purification of full-length Mid1p for biophysical analysis, and lack of knowledge about the structural domains of Mid1p limits functional analysis. We addressed these limitations by identifying in a bacterial expression screen of random Mid1p fragments five soluble segments that can...

Women with dense breast tissue on mammography are at higher risk of developing breast cancer but the underlying mechanisms are not well understood. De-regulation of microRNAs (miRNAs) has been associated with the onset of breast cancer. miRNAs in the extracellular space participate in the regulation of the local tissue microenvironment. Here, we recruited 39 healthy postmenopausal women attendi...