There is increasing evidence that miRNA and transcription factors interact in an instructive fashion in normal and malignant hematopoiesis. We explored the impact of TEL-AML1 (ETV6-RUNX1), the most common fusion protein in childhood leukemia, on miRNA expression and the leukemic phenotype. Using RNA interference, miRNA expression arrays, and quantitative polymerase chain reaction, we identified...

15.1 Emerging Compound Classes and Relevance to Herpetofauna .........................................494 15.1.1 Brominated Flame Retardants ..............................................................................494 15.1.2 Perfluorinated Chemicals......................................................................................496 15.1.3 Anionic Surfactants..............................

OBJECTIVE To evaluate the efficacy and safety of ABT-494, a selective JAK-1 inhibitor, in patients with moderate-to-severe rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX). METHODS Three hundred RA patients receiving stable doses of MTX were randomly assigned equally to receive immediate-release ABT-494 at 3, 6, 12, or 18 mg twice daily, 24 mg once daily, or placebo ...

Oral squamous cell carcinoma (OSCC) is the most common malignancy of head and neck. Although radiotherapy is used for OSCC treatment, the occurrence of radioresistant cancer cells limits its efficiency. MicroRNAs (miRNAs) are non-coding RNAs with lengths of 18-25 base pairs and known to be involved in carcinogenesis. We previously demonstrated that by targeting B lymphoma Mo-MLV insertion regio...

The Promise of ASSIST: Shaping the Future ............................................................... 484 Ecological Theory and the ASSIST Conceptual Framework ................................................. 484 Interventions for Systems-Level Change ........................................................................... 484 Media Advocacy ................................................

TaGW2 is an orthologue of rice gene OsGW2, which encodes E3 RING ubiquitin ligase and controls the grain size in rice. In wheat, three copies of TaGW2 have been identified and mapped on wheat homoeologous group 6 viz. TaGW2-6A, TaGW2-6B and TaGW2-6D. In the present study, using as many as 207 Indian wheat genotypes, we identified four SNPs including two novel SNPs (SNP-988 and SNP-494) in the p...

Abstract Background Pigmented epithelioid melanocytomas (PEMs) pose a challenge in terms of diagnosis and management, this is due to the wide spectrum disease severity. Not only management grey area, but there controversy over follow up, their indeterminate malignant potential. Case An 11-year-old boy presented with six-month history rapidly changing pigmented naevus on his upper back. He had F...

INTRODUCTION. .................................................................. 488 Description of Drosophila simulans. ................................................ 488 Distribution of Drosophila simulans ................................................ 491 Discovery of Drosophila simulans. ................................................. 491 Drosophila melanogaster 0 X D . simulans 61. ....