The disease has four main causes: sebaceous hyperplasia and hyperseborrhoea; hyperkeratinization and consequent keratinocyte accession; colonization of Propionibacterium acnes (P. acnes) and respective Staphylococcus albus and inflammation and immune response. The production of sebum by sebocytes is stimulated by androgens, such as testosterone, which in turn stimulate the production of sebocyt...

Neuroactive testosterone metabolites synthesized by enzymes 5α-reductase and 3α/3β-hydroxysteroid oxidoreductase are critical physiological modulators of the central nervous system (CNS) function. Indeed, as discussed in this review, they exert a variety effects on myelination, brain maturation, neurotransmission, reproductive behavior, stress responses. The expression synthesis these well leve...

CONTEXT: Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy has demonstrated an improved metabolic profile compared to conventional 3-times-daily (TID-HC) among patients with primary adrenal insufficiency. This effect might be related a more physiological cortisol profile, but also modified pattern of metabolism. OBJECTIVE: work aimed study metabolism during DR-HC and TID-H...

Long-term depression (LTD) induced by low-frequency electrical stimulation (LFS) in the CA1 region of the hippocampus is a form of synaptic plasticity thought to contribute to learning and memory and to the pathophysiology of neuropsychiatric disorders. In naïve hippocampal slices from juvenile rats, we previously found that LTD induction can impair subsequent induction of long-term potentiatio...

Today the problem of treatment patients with benign prostatic hyperplasia (BPH) is actual one. BPH an age-related chronic progressive disease. It especially relevant for men over age 50 years. According to WHO demographic data, world’s population becoming older, so incidence going increase, that leads a significant decline in quality life due dysfunction lower urinary tract and presence symptom...

5α-Reductases irreversibly catalyse A-ring reduction of pregnene steroids, including glucocorticoids and androgens. Genetic disruption of 5α-reductase 1 in male mice impairs glucocorticoid clearance and predisposes to glucose intolerance and hepatic steatosis upon metabolic challenge. However, it is unclear whether this is driven by changes in androgen and/or glucocorticoid action. Female mice ...

Steroid 5α-reductase is the enzyme that converts testosterone to 5α-dihydrotestosterone (DHT). Two isoenzymes have been identified, namely type 1 and type 2 [1]. The conversion of testosterone to DHT is irreversible and the androgenic potency of DHT was shown to be at least 2–5 times stronger than that of testosterone [2, 3]. The hyperactivity of this enzyme is, therefore, supposed to play an i...

Testosterone (T) stimulates erythropoiesis and regulates iron homeostasis. However, it remains unknown whether the (type II) 5α-reduction of T to dihydrotestosterone (DHT) mediates these androgenic effects, as it does in some other tissues. Our purpose was to determine whether inhibition of type II 5α-reductase (via finasteride) alters red blood cell (RBC) production and serum markers of iron h...

Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men and causes lower urinary tract symptoms due to excessive proliferation prostate stromal epithelial cells. The present study investigated improving effect BenPros, an edible natural product mixture (green tea extract, soybean extract camellia japonica oil), against development BPH vitro vivo. BenPros treatment s...