The authors present a procedure for resource allocation among transit agencies for transit fleet management, specifically focusing on the purchase of new buses and rebuilding of existing buses. The model is formulated as a non-linear optimization problem of maximizing the total weighted average remaining life of the fleet subject to budgetary, policy and other constraints. The problem is solved...

some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic...

This Application Note describes the use of the RNA 6000 Pico LabChip kit for the quality control of small amounts of RNA using the Agilent 2100 bioanalyzer. The main advantages of the RNA 6000 Pico LabChip kit are its high sensitivity combined with its time saving experimental procedure. Here, we show experimental data that demonstrate the sensitivity of the RNA 6000 Pico LabChip kit by the ana...

The 2-min protocol (1 + 1) for the betaeta-s.t.a.r. (manufactured by Neogen Corporation, Lansing, MI, USA) was validated at the Technology and Food Science Unit of the Institute for Agricultural and Fisheries Research according to Commission Decision 2002/657/EC. The test was very selective for the group of beta-lactam compounds: the only interference found was by clavulanic acid at 2500 microg...

We aimed to develop a high-throughput screening (HTS) system for preliminary predictions of human skin permeability by using an artificial membrane that can mimic the permeation behaviour of lipophilic and hydrophilic compounds across the human skin. In this study, we synthesized a copolymer containing poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) (PEG) 6000 and impregnated it onto a ...